FEZ1 and UBE4B

Data Source:
BioGRID (enzymatic study)

		FEZ1	UBE4B
Description		fasciculation and elongation protein zeta 1	ubiquitination factor E4B
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Golgi Apparatus Centrosome Microtubule Plasma Membrane Axon Dendrite Growth Cone Neuronal Cell Body	Ubiquitin Ligase Complex Nucleus Cytoplasm
	Molecular Function	Protein Kinase C Binding Protein Binding Gamma-tubulin Binding Protein N-terminus Binding	Enzyme Binding Ubiquitin-ubiquitin Ligase Activity ATPase Binding
	Biological Process	Cell Adhesion Nervous System Development Axon Guidance Positive Regulation Of Neuron Projection Development Hippocampus Development Establishment Of Cell Polarity Positive Regulation Of Neuron Differentiation Establishment Of Mitochondrion Localization Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Mitochondrion Morphogenesis Cellular Response To Growth Factor Stimulus Negative Regulation Of Autophagosome Assembly	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Granzyme-mediated Apoptotic Signaling Pathway Response To UV Ubiquitin-dependent ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS		Breast cancer (survival) ( 25890600) Schizophrenia ( 22688191 23894747)	Atrial fibrillation ( 29892015) Hepatocellular carcinoma ( 20676096) Resting heart rate ( 27798624)
Interacting Genes		57 interacting genes: BARD1 BORA BRD1 C8orf33 CCL7 CEP126 CIB1 CLASP2 COL9A2 CSTF2 DIS3L2 DISC1 DNAAF5 DRAP1 FEZ2 GEMIN7 GTF2F1 HAP1 HTATSF1 HTT IMMT LRIF1 MEST NBR1 NDUFB9 NEK1 OLFML3 P4HB PAM16 PDCD7 PPP4R3B PRKCZ PTH PTN PTPRS RAB3GAP1 RAB3GAP2 RAI14 RIF1 SAP30L SCOC SERPINH1 SMARCD1 SMC3 STAR TAC3 TAF1D TAF9 TBC1D25 TEDC2 TLK2 TOMM20 TTR TXNDC9 UBE4B WWC1 ZNF251	22 interacting genes: ATXN3 CASP3 CASP6 CASP7 CDKN2A DNAJC7 ESR1 FEZ1 GZMB HGS HRAS MAPK3 OTUB1 PGAM5 PPP3CA PRMT1 RAD23A TRIP12 UBE2D2 UBE2D3 VAV2 VCP
Entrez ID		9638	10277
HPRD ID		09212	11659
Ensembl ID		ENSG00000149557	ENSG00000130939
Uniprot IDs		Q99689	O95155
PDB IDs			2KRE 3L1X 3L1Z 5O75
Enriched GO Terms of Interacting Partners?
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