MYOZ1 and PNKP

Data Source:
HPRD (two hybrid)

		MYOZ1	PNKP
Description		myozenin 1	polynucleotide kinase 3'-phosphatase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Actin Cytoskeleton Z Disc Pseudopodium	Nucleus Nucleoplasm Nucleolus Mitochondrion Membrane
	Molecular Function	Actin Binding Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Telethonin Binding FATZ Binding	Damaged DNA Binding Double-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding Purine Nucleotide Binding Polynucleotide 3'-phosphatase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Myofibril Assembly Negative Regulation Of Phosphoprotein Phosphatase Activity Wound Healing Negative Regulation Of Skeletal Muscle Tissue Regeneration Skeletal Muscle Fiber Adaptation Sarcomere Organization Negative Regulation Of Calcineurin-NFAT Signaling Cascade	Nucleotide-excision Repair, DNA Damage Removal DNA-dependent DNA Replication DNA Repair Response To Oxidative Stress Response To Radiation Negative Regulation Of Protein ADP-ribosylation Dephosphorylation Positive Regulation Of Telomere Maintenance Via Telomerase DNA Damage Response, Detection Of DNA Damage Nucleotide Phosphorylation Positive Regulation Of Telomerase Activity Nucleic Acid Phosphodiester Bond Hydrolysis Polynucleotide 3' Dephosphorylation Positive Regulation Of Telomere Capping Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways			APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Atrial fibrillation ( 30061737) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		40 interacting genes: ACTN1 ACTN2 ACTN3 ACTN4 AKAP8L APP BAG4 BRCA1 CEACAM6 CEP76 CRX EIF3F EXOSC8 FLNA FLNC GOLGA6A GRB2 KRT34 KRT36 KRTAP12-2 LDB3 LHX4 LZTS2 MAGEA11 PFDN5 PLEKHG4 PNKP PNMA1 PRKAA2 TCAP TRAF1 TRIM23 TRIM55 TRIM63 USHBP1 VAC14 VBP1 WASHC3 WWOX YPEL3	49 interacting genes: APP CACFD1 CAMK2B CARD10 CCDC14 CCDC43 CISD2 CNTROB COL17A1 DVL3 FADS6 GAS8 GZMK IKZF1 KANK2 KDM1A KLHL12 KRTAP4-12 LMNA MAGEA11 MCC MEOX2 MGST2 MSANTD4 MYOZ1 OBI1 PICK1 PNMA5 POLB PSTPIP1 RPRM SFT2D1 SMAD5 SNX2 SP4 SUV39H1 SYNGR1 SYNGR3 SYP TARBP2 TBC1D1 THAP1 TMEM239 TNIP1 TRIM37 XRCC1 XRCC4 ZBTB14 ZNF639
Entrez ID		58529	11284
HPRD ID		05725	09284
Ensembl ID		ENSG00000177791	ENSG00000039650
Uniprot IDs		Q9NP98	Q96T60
PDB IDs			2BRF 2W3O
Enriched GO Terms of Interacting Partners?
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