RARA and BAG1

Data Source:
HPRD (in vivo, two hybrid)

		RARA	BAG1
Description		retinoic acid receptor alpha	BAG cochaperone 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cell Surface Actin Cytoskeleton Protein-containing Complex	Nucleus Cytoplasm Cytosol Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Retinoic Acid Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Signaling Receptor Binding Protein Binding Transcription Factor Binding Zinc Ion Binding Enzyme Binding Protein Domain Specific Binding Chromatin DNA Binding Protein Kinase B Binding Retinoic Acid-responsive Element Binding Protein Kinase A Binding Alpha-actinin Binding Sequence-specific Double-stranded DNA Binding	Adenyl-nucleotide Exchange Factor Activity Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Chaperone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Signal Transduction Positive Regulation Of Cell Population Proliferation Hormone-mediated Signaling Pathway Cell Differentiation Negative Regulation Of Granulocyte Differentiation Response To Retinoic Acid Negative Regulation Of Interferon-gamma Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Apoptotic Cell Clearance Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Binding Cellular Response To Estrogen Stimulus	Apoptotic Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Protein Stabilization Chaperone Cofactor-dependent Protein Refolding Regulation Of Cellular Response To Heat
Pathways		Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis	Regulation of HSF1-mediated heat shock response
Drugs		Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Isotretinoin Tamibarotene LGD-1550 Trifarotene	(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Diseases		Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Acute myeloid leukemia (AML)
GWAS		Asthma ( 31619474)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		97 interacting genes: ACTN4 AKT1 ALOX15B ALX1 ARID1A ARID5A ARNTL BAG1 BBS4 BTG1 CCND3 CCNDBP1 CDK7 CEBPA CLOCK CNOT1 COPS2 E2F1 ESR1 FGFR1 FN1 FOXO1 GADD45G GATA2 HDAC1 HDAC3 HDAC4 HMGA1 HR IRX4 ITGB1BP2 KAT2B KDM5A KLF5 LRIF1 MAPK6 MCRS1 MDM2 MECR MED1 MED25 MED6 MMS19 NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR2C1 NR2E3 NR3C1 NRBF2 NRIP1 NRIP2 NSD1 PARP1 PHF8 PIN1 PLEKHF2 PML PNRC2 POU2F1 PPARG PRAME PRDX6 PRKCA PSMC5 RXRA RXRB RXRG S100A3 SIRT1 SMARCD3 SNW1 SP1 SPEN SRC SRF STAT5B TADA3 TEKT4 THRB TNIP1 TOP2B TRIB3 TRIM24 TRIP4 UBE3A UBQLN1 USP7 ZBTB16	28 interacting genes: AR ARRB1 BCL2 BCL2L1 ESR1 HBEGF HSPA1A HSPA1B HSPA4 HSPA8 LRRK1 LRRK2 MAPT MET NR3C1 PDGFRB PPP1R15A PSMD1 PSMD2 PYGL RAF1 RARA RB1 SIAH1 STUB1 TRIM23 TRIM27 VDR
Entrez ID		5914	573
HPRD ID		06769	03292
Ensembl ID		ENSG00000131759	ENSG00000107262
Uniprot IDs		A8K840 A8MUP8 F1D8N9 P10276 Q6I9R7	Q99933
PDB IDs		1DKF 1DSZ 3A9E 3KMR 3KMZ 4DQM 5K13 6XWG	1HX1 1WXV 3FZF 3FZH 3FZK 3FZL 3FZM 3LDQ 3M3Z 5AQF 5AQG 5AQH 5AQI 5AQJ 5AQK 5AQL 5AQM 5AQN 5AQO 5AQP 5AQQ 5AQR 5AQS 5AQT 5AQU 5AQV
Enriched GO Terms of Interacting Partners?
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