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RARA and PLEKHF2
Data Source:
BioGRID
(two hybrid)
RARA
PLEKHF2
Description
retinoic acid receptor alpha
pleckstrin homology and FYVE domain containing 2
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Cell Surface
Actin Cytoskeleton
Protein-containing Complex
Endoplasmic Reticulum
Transport Vesicle
Early Endosome Membrane
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Retinoic Acid Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Signaling Receptor Binding
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
Enzyme Binding
Protein Domain Specific Binding
Chromatin DNA Binding
Protein Kinase B Binding
Retinoic Acid-responsive Element Binding
Protein Kinase A Binding
Alpha-actinin Binding
Sequence-specific Double-stranded DNA Binding
Protein Binding
Phosphatidylinositol Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Protein Phosphorylation
Signal Transduction
Positive Regulation Of Cell Population Proliferation
Hormone-mediated Signaling Pathway
Cell Differentiation
Negative Regulation Of Granulocyte Differentiation
Response To Retinoic Acid
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Interleukin-13 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-5 Production
Apoptotic Cell Clearance
Positive Regulation Of T-helper 2 Cell Differentiation
Positive Regulation Of Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Retinoic Acid Receptor Signaling Pathway
Positive Regulation Of Binding
Cellular Response To Estrogen Stimulus
Protein Transport
Pathways
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
Signaling by Retinoic Acid
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
Drugs
Adapalene
Acitretin
Alitretinoin
Tretinoin
Tazarotene
Etretinate
Isotretinoin
Tamibarotene
LGD-1550
Trifarotene
Diseases
Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
Acute myeloid leukemia (AML)
GWAS
Asthma (
31619474
)
Radiation response (
20923822
)
Interacting Genes
97 interacting genes:
ACTN4
AKT1
ALOX15B
ALX1
ARID1A
ARID5A
ARNTL
BAG1
BBS4
BTG1
CCND3
CCNDBP1
CDK7
CEBPA
CLOCK
CNOT1
COPS2
E2F1
ESR1
FGFR1
FN1
FOXO1
GADD45G
GATA2
HDAC1
HDAC3
HDAC4
HMGA1
HR
IRX4
ITGB1BP2
KAT2B
KDM5A
KLF5
LRIF1
MAPK6
MCRS1
MDM2
MECR
MED1
MED25
MED6
MMS19
NCOA1
NCOA2
NCOA3
NCOA6
NCOR1
NCOR2
NKX2-1
NPAS2
NR0B2
NR1H2
NR1H3
NR2C1
NR2E3
NR3C1
NRBF2
NRIP1
NRIP2
NSD1
PARP1
PHF8
PIN1
PLEKHF2
PML
PNRC2
POU2F1
PPARG
PRAME
PRDX6
PRKCA
PSMC5
RXRA
RXRB
RXRG
S100A3
SIRT1
SMARCD3
SNW1
SP1
SPEN
SRC
SRF
STAT5B
TADA3
TEKT4
THRB
TNIP1
TOP2B
TRIB3
TRIM24
TRIP4
UBE3A
UBQLN1
USP7
ZBTB16
168 interacting genes:
ABCG4
ACY3
ADAP1
AIDA
AIMP2
ANO9
APP
APPL1
ARID4B
ARL14EP
ASPH
BARHL2
BCAS2
BCAS3
BEND7
BLOC1S6
BOD1
BRD7
BSCL2
C11orf45
C1orf35
C3
CAVIN2
CBX8
CCDC146
CCDC172
CCDC25
CCDC85B
CDC20B
CEP44
CERK
CGGBP1
CHCHD2
CHIC2
COX5B
CRYBA1
DAZAP2
DMRT3
DNAAF11
DOCK2
DOCK3
DPPA4
DRAP1
DTX2
DUSP4
DUT
EIF3C
EML2
EXOC7
FAH
FBXO28
FBXW5
FGF13
FHL3
FLNA
FRMD8
GAGE12G
GAGE2E
GEM
GFER
GLUL
GNMT
GPBP1
GPBP1L1
GRAMD4
GTPBP2
HEBP2
HSPB7
INO80
KCNAB3
KRTAP10-10
KRTAP5-4
L3MBTL3
LDOC1
MAGI2
MAP2K1
MAX
MBIP
MBP
MEAF6
MFAP1
MIDN
MPP4
MRI1
NDUFA5
NFIA
NONO
NPM2
NSD2
NUDT2
NUTM1
P2RX7
PACSIN1
PAK1IP1
PDK4
PIK3R3
PPCDC
PPP1R18
PRDM14
PRKAG1
PRKAR1A
PRPSAP1
PTPN3
PWWP2A
RAB28
RABAC1
RADX
RARA
RASGEF1B
RGS10
RGS8
RPAP2
RPE
RPRM
RPS21
RSPO2
RTN1
RTN3
RTN4
S100A1
S100A13
SAMD11
SCYL1
SEC14L4
SEPTIN2
SEPTIN5
SEPTIN6
SETBP1
SFN
SNRNP35
SOST
SPATA24
SPEF1
SPON2
STAMBPL1
SYT16
TBCEL
TBX3
TCEANC
THAP10
THG1L
TNFAIP8
TNFAIP8L1
TP53BP2
TRAF6
TRAM1L1
TRAPPC3
TRIAP1
TRIM22
TSC22D3
TTC9C
TXNL4B
UBE2Z
UGP2
USF1
XCR1
XRN2
YIF1A
YY1
ZBTB6
ZDHHC24
ZFYVE26
ZNF165
ZNF250
ZNF263
ZNF398
ZNF439
ZNF581
Entrez ID
5914
79666
HPRD ID
06769
15147
Ensembl ID
ENSG00000131759
ENSG00000175895
Uniprot IDs
A8K840
A8MUP8
F1D8N9
P10276
Q6I9R7
Q9H8W4
PDB IDs
1DKF
1DSZ
3A9E
3KMR
3KMZ
4DQM
5K13
6XWG
Enriched GO Terms of Interacting Partners
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