FGF7 and DUSP3

Data Source:
HPRD (in vitro)

		FGF7	DUSP3
Description		fibroblast growth factor 7	dual specificity phosphatase 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus	Immunological Synapse Nucleus Nucleoplasm Cytosol
	Molecular Function	Fibroblast Growth Factor Receptor Binding Type 2 Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity	Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity Protein Kinase Binding Receptor Tyrosine Kinase Binding MAP Kinase Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity Protein Tyrosine Kinase Binding
	Biological Process	MAPK Cascade Positive Regulation Of Protein Phosphorylation Signal Transduction Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Response To Wounding Animal Organ Morphogenesis Mesenchymal Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Keratinocyte Proliferation Cell Differentiation Lung Development Regulation Of Cell Migration Hair Follicle Morphogenesis Actin Cytoskeleton Reorganization Protein Localization To Cell Surface Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Keratinocyte Migration Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Branching Involved In Salivary Gland Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Secretion By Lung Epithelial Cell Involved In Lung Growth	Inactivation Of MAPK Activity Dephosphorylation Negative Regulation Of Cell Migration Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of Chemotaxis Regulation Of Focal Adhesion Assembly Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Focal Adhesion Disassembly Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity
Pathways		PI3K Cascade PIP3 activates AKT signaling FGFR2b ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR2 PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling Negative regulation of FGFR2 signaling Signaling by FGFR2 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	ERKs are inactivated
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Lung adenocarcinoma ( 28604730) Thyroid hormone levels ( 23408906) Thyroid volume ( 21565293)	Fractures ( 30158200) HDL cholesterol ( 25961943 27036123) Metabolite levels ( 23823483) Triglycerides ( 25961943)
Interacting Genes		14 interacting genes: COL1A1 COL2A1 COL3A1 COL6A1 DESI1 DUSP3 FGFR1 FGFR2 FGFR3 FGFR4 HSPG2 NRP1 PTX3 UBQLN1	15 interacting genes: APP BNIP3L CASK EGF EGFR FGF7 MAP2K2 MAPK1 MAPK3 MEOX1 NEUROD1 PDGFA STAT1 SYK ZAP70
Entrez ID		2252	1845
HPRD ID		01022	02553
Ensembl ID		ENSG00000140285	ENSG00000108861
Uniprot IDs		P21781	P51452
PDB IDs			1J4X 1VHR 3F81
Enriched GO Terms of Interacting Partners?
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