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DUSP3 and PDGFA
Data Source:
HPRD
(in vitro)
DUSP3
PDGFA
Description
dual specificity phosphatase 3
platelet derived growth factor subunit A
Image
GO Annotations
Cellular Component
Immunological Synapse
Nucleus
Nucleoplasm
Cytosol
Golgi Membrane
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Golgi Lumen
Microvillus
Cell Surface
Platelet Alpha Granule Lumen
Molecular Function
Protein Tyrosine Phosphatase Activity
Protein Binding
Cytoskeletal Protein Binding
Protein Tyrosine/serine/threonine Phosphatase Activity
Phosphatase Activity
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
MAP Kinase Phosphatase Activity
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Protein Tyrosine Kinase Binding
Platelet-derived Growth Factor Receptor Binding
Protein Binding
Collagen Binding
Growth Factor Activity
Protein Homodimerization Activity
Protein Heterodimerization Activity
Platelet-derived Growth Factor Binding
Growth Factor Receptor Binding
Biological Process
Inactivation Of MAPK Activity
Dephosphorylation
Negative Regulation Of Cell Migration
Peptidyl-tyrosine Dephosphorylation
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of MAPK Cascade
Positive Regulation Of Mitotic Cell Cycle
Negative Regulation Of JNK Cascade
Negative Regulation Of T Cell Receptor Signaling Pathway
Negative Regulation Of T Cell Activation
Negative Regulation Of Chemotaxis
Regulation Of Focal Adhesion Assembly
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Focal Adhesion Disassembly
Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity
MAPK Cascade
Angiogenesis
Cell Activation
Hair Follicle Development
Positive Regulation Of Mesenchymal Cell Proliferation
Platelet Degranulation
Cell-cell Signaling
Positive Regulation Of Cell Population Proliferation
Response To Wounding
Animal Organ Morphogenesis
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Negative Regulation Of Platelet Activation
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Regulation Of Smooth Muscle Cell Migration
Cell Projection Assembly
Actin Cytoskeleton Organization
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Protein Autophosphorylation
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Wound Healing
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Skin Development
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Fibroblast Proliferation
Lung Alveolus Development
Regulation Of Peptidyl-tyrosine Phosphorylation
Negative Chemotaxis
Positive Regulation Of Cell Division
Positive Regulation Of Protein Kinase B Signaling
Regulation Of Branching Involved In Salivary Gland Morphogenesis By Epithelial-mesenchymal Signaling
Positive Regulation Of ERK1 And ERK2 Cascade
Regulation Of Glomerular Mesangial Cell Proliferation
Embryonic Lung Development
Regulation Of DNA Biosynthetic Process
Pathways
ERKs are inactivated
Non-integrin membrane-ECM interactions
Drugs
Diseases
Malignant pleural mesothelioma
Glioma
GWAS
Fractures (
30158200
)
HDL cholesterol (
25961943
27036123
)
Metabolite levels (
23823483
)
Triglycerides (
25961943
)
Male-pattern baldness (
28196072
)
Interacting Genes
15 interacting genes:
APP
BNIP3L
CASK
EGF
EGFR
FGF7
MAP2K2
MAPK1
MAPK3
MEOX1
NEUROD1
PDGFA
STAT1
SYK
ZAP70
17 interacting genes:
A2M
ASPH
COL1A1
COL1A2
COL2A1
COL3A1
COL4A1
COL5A1
COL6A1
DUSP3
FURIN
HSPG2
MBD3
MDFI
PDAP1
PDGFRA
SPARC
Entrez ID
1845
5154
HPRD ID
02553
01424
Ensembl ID
ENSG00000108861
ENSG00000197461
Uniprot IDs
P51452
P04085
PDB IDs
1J4X
1VHR
3F81
3MJK
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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