DUSP3

Description		dual specificity phosphatase 3
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GO Annotations	Cellular Component	Immunological Synapse Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity Protein Kinase Binding Receptor Tyrosine Kinase Binding MAP Kinase Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity Protein Tyrosine Kinase Binding
	Biological Process	Inactivation Of MAPK Activity Dephosphorylation Negative Regulation Of Cell Migration Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of Chemotaxis Regulation Of Focal Adhesion Assembly Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Focal Adhesion Disassembly Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity
Pathways		ERKs are inactivated
Drugs
Diseases
GWAS		Fractures ( 30158200) HDL cholesterol ( 25961943 27036123) Metabolite levels ( 23823483) Triglycerides ( 25961943)
Interacting Genes		15 interacting genes: APP BNIP3L CASK EGF EGFR FGF7 MAP2K2 MAPK1 MAPK3 MEOX1 NEUROD1 PDGFA STAT1 SYK ZAP70
Entrez ID		1845
HPRD ID		02553
Ensembl ID		ENSG00000108861
Uniprot IDs		P51452
PDB IDs		1J4X 1VHR 3F81
Enriched GO Terms of Interacting Partners?
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