DUSP3 and MAP2K2

Data Source:
HPRD (in vivo, in vitro)

		DUSP3	MAP2K2
Description		dual specificity phosphatase 3	mitogen-activated protein kinase kinase 2
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GO Annotations	Cellular Component	Immunological Synapse Nucleus Nucleoplasm Cytosol	Extracellular Region Nucleus Mitochondrion Early Endosome Late Endosome Peroxisomal Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Microtubule Cell-cell Junction Focal Adhesion Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity Protein Kinase Binding Receptor Tyrosine Kinase Binding MAP Kinase Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity Protein Tyrosine Kinase Binding	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding PDZ Domain Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Scaffold Protein Binding
	Biological Process	Inactivation Of MAPK Activity Dephosphorylation Negative Regulation Of Cell Migration Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of Chemotaxis Regulation Of Focal Adhesion Assembly Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Focal Adhesion Disassembly Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity	MAPK Cascade Activation Of MAPK Activity Negative Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Regulation Of Stress-activated MAPK Cascade Peptidyl-serine Autophosphorylation Positive Regulation Of Transcription, DNA-templated ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Golgi Inheritance Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Regulation Of Early Endosome To Late Endosome Transport
Pathways		ERKs are inactivated	MAPK1 (ERK2) activation Frs2-mediated activation Signal transduction by L1 Uptake and function of anthrax toxins RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by MAP2K mutants Signaling by RAF1 mutants
Drugs			Bosutinib Trametinib Selumetinib Binimetinib Fostamatinib
Diseases			Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Fractures ( 30158200) HDL cholesterol ( 25961943 27036123) Metabolite levels ( 23823483) Triglycerides ( 25961943)	Eosinophil counts ( 32888494) Heel bone mineral density ( 30598549) Height ( 29782485) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Pulse pressure ( 30224653) White blood cell count ( 32888494)
Interacting Genes		15 interacting genes: APP BNIP3L CASK EGF EGFR FGF7 MAP2K2 MAPK1 MAPK3 MEOX1 NEUROD1 PDGFA STAT1 SYK ZAP70	20 interacting genes: ARAF BRAF CASP9 CCNDBP1 CNKSR1 COPS5 DUSP3 GRIN1 GRIN2D HNRNPK LAMTOR3 LIG4 MAPK1 MAPK3 MAPK8 MOS RAF1 RGS12 RIPOR2 ZNF207
Entrez ID		1845	5605
HPRD ID		02553	03164
Ensembl ID		ENSG00000108861	ENSG00000126934
Uniprot IDs		P51452	P36507
PDB IDs		1J4X 1VHR 3F81	1S9I 4H3Q
Enriched GO Terms of Interacting Partners?
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