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DUSP3 and MAPK3
Data Source:
HPRD
(in vivo, in vitro)
DUSP3
MAPK3
Description
dual specificity phosphatase 3
mitogen-activated protein kinase 3
Image
GO Annotations
Cellular Component
Immunological Synapse
Nucleus
Nucleoplasm
Cytosol
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Mitochondrion
Early Endosome
Late Endosome
Golgi Apparatus
Cytosol
Cytoskeleton
Plasma Membrane
Caveola
Focal Adhesion
Pseudopodium
Protein-containing Complex
Molecular Function
Protein Tyrosine Phosphatase Activity
Protein Binding
Cytoskeletal Protein Binding
Protein Tyrosine/serine/threonine Phosphatase Activity
Phosphatase Activity
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
MAP Kinase Phosphatase Activity
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Protein Tyrosine Kinase Binding
Phosphotyrosine Residue Binding
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
MAP Kinase Kinase Activity
Protein Binding
ATP Binding
Phosphatase Binding
Identical Protein Binding
Scaffold Protein Binding
Biological Process
Inactivation Of MAPK Activity
Dephosphorylation
Negative Regulation Of Cell Migration
Peptidyl-tyrosine Dephosphorylation
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of MAPK Cascade
Positive Regulation Of Mitotic Cell Cycle
Negative Regulation Of JNK Cascade
Negative Regulation Of T Cell Receptor Signaling Pathway
Negative Regulation Of T Cell Activation
Negative Regulation Of Chemotaxis
Regulation Of Focal Adhesion Assembly
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Focal Adhesion Disassembly
Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity
MAPK Cascade
Activation Of MAPKK Activity
Activation Of MAPK Activity
Positive Regulation Of Protein Phosphorylation
Transcription Initiation From RNA Polymerase I Promoter
Protein Phosphorylation
Apoptotic Process
DNA Damage Induced Protein Phosphorylation
Cell Cycle
Cell Surface Receptor Signaling Pathway
Axon Guidance
Aging
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Toxic Substance
Positive Regulation Of Gene Expression
Positive Regulation Of Macrophage Chemotaxis
Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Phosphorylation
Peptidyl-serine Phosphorylation
Sensory Perception Of Pain
Arachidonic Acid Metabolic Process
Platelet Activation
Regulation Of Ossification
BMP Signaling Pathway
Regulation Of Cellular PH
Thyroid Gland Development
Positive Regulation Of Cyclase Activity
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Histone Phosphorylation
Cellular Response To Amino Acid Starvation
Cellular Response To Reactive Oxygen Species
Positive Regulation Of Histone Acetylation
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Outer Ear Morphogenesis
Response To Exogenous DsRNA
Positive Regulation Of Translation
Positive Regulation Of Transcription By RNA Polymerase II
Decidualization
Thymus Development
Regulation Of DNA-binding Transcription Factor Activity
Cartilage Development
Stress-activated MAPK Cascade
Regulation Of Cytoskeleton Organization
Positive Regulation Of Telomerase Activity
Bergmann Glial Cell Differentiation
Face Development
Lung Morphogenesis
Trachea Formation
Cardiac Neural Crest Cell Development Involved In Heart Development
Protein-containing Complex Assembly
ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Interleukin-1-mediated Signaling Pathway
Response To Epidermal Growth Factor
Cellular Response To Mechanical Stimulus
Cellular Response To Cadmium Ion
Cellular Response To Tumor Necrosis Factor
Caveolin-mediated Endocytosis
Regulation Of Golgi Inheritance
Positive Regulation Of Macrophage Proliferation
Regulation Of Cellular Response To Heat
Cellular Response To Dopamine
Positive Regulation Of Telomere Capping
Positive Regulation Of Xenophagy
Regulation Of Early Endosome To Late Endosome Transport
Negative Regulation Of Apolipoprotein Binding
Pathways
ERKs are inactivated
MAPK3 (ERK1) activation
RAF-independent MAPK1/3 activation
ISG15 antiviral mechanism
Spry regulation of FGF signaling
Frs2-mediated activation
ERK/MAPK targets
ERK/MAPK targets
ERKs are inactivated
Regulation of actin dynamics for phagocytic cup formation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Oncogene Induced Senescence
FCERI mediated MAPK activation
Regulation of HSF1-mediated heat shock response
NCAM signaling for neurite out-growth
RSK activation
Signal transduction by L1
Activation of the AP-1 family of transcription factors
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate NADPH Oxidases
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RNA Polymerase I Promoter Opening
Signal attenuation
Advanced glycosylation endproduct receptor signaling
Gastrin-CREB signalling pathway via PKC and MAPK
ESR-mediated signaling
RUNX2 regulates osteoblast differentiation
Regulation of PTEN gene transcription
Regulation of the apoptosome activity
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Suppression of apoptosis
Signaling downstream of RAS mutants
Signaling by MAP2K mutants
Signaling by RAF1 mutants
FCGR3A-mediated phagocytosis
Growth hormone receptor signaling
Drugs
Sulindac
Acetylsalicylic acid
Minocycline
Arsenic trioxide
Purvalanol
5-iodotubercidin
Seliciclib
Cholecystokinin
Ulixertinib
Diseases
GWAS
Fractures (
30158200
)
HDL cholesterol (
25961943
27036123
)
Metabolite levels (
23823483
)
Triglycerides (
25961943
)
Autism spectrum disorder or schizophrenia (
28540026
)
Blood protein levels (
30072576
)
Brain morphology (MOSTest) (
32665545
)
Childhood body mass index (
33045005
)
Hodgkin's lymphoma (
30194254
)
Multiple sclerosis (
31604244
24076602
)
Pubertal anthropometrics (
23449627
)
Schizophrenia (
28991256
25056061
29483656
)
Tonsillectomy (
27182965
28928442
)
Waist circumference (
28552196
)
Weight (
28552196
)
Interacting Genes
15 interacting genes:
APP
BNIP3L
CASK
EGF
EGFR
FGF7
MAP2K2
MAPK1
MAPK3
MEOX1
NEUROD1
PDGFA
STAT1
SYK
ZAP70
186 interacting genes:
AKR1C1
AMOT
ARRB1
ATP1A1
AURKA
BCL2
BCL3
BRAF
BTBD10
BUB1
C1QBP
CASP8
CASP9
CAV1
CCDC6
CDC23
CDC25C
CDC45
CDH1
CDKN2A
CEBPB
CPXM1
CREBBP
CREM
CRP
CTNND1
CUEDC2
DAPK1
DCC
DCP1A
DLC1
DUSP1
DUSP10
DUSP3
DUSP4
DUSP5
DUSP6
DUSP9
EGFR
ELK1
ELK4
EPOR
ESR1
ETS1
ETV1
FBXW7
FCGR2B
FKBP2
FOS
FOXP2
FRS2
GAB1
GAB2
GATA1
GATA4
GJA1
GMFB
GRK2
GTF2I
HDAC4
HDAC6
HIF1A
HMMR
HNF4A
HSF1
HSF4
HSPB8
HTRA2
ID2
IER3
INSR
IRS1
ITGAV
ITGB3
JUN
JUND
KRT8
KSR2
L3MBTL3
LAMTOR3
LCK
LIPE
LRPAP1
LRRC4
LYN
MAFG
MAGEA11
MAGED1
MAP2K1
MAP2K2
MAP2K3
MAP3K14
MAPK14
MAPK8
MAPKAPK2
MAPT
MBP
MED1
METAP2
MKNK1
MYC
MYLK
MYOG
NAB2
NCKIPSD
NGFR
NRAS
NTRK1
NTRK3
NUP153
NUP58
PAK2
PDE6G
PDGFRL
PEA15
PFKM
PLAT
PLCB1
PPARA
PPP1CA
PPP2CA
PRKCD
PRKCE
PRKCZ
PTPN11
PTPN5
PTPN7
PTPRE
PTPRR
PXN
RAB4A
RAF1
RALGDS
RB1
RCAN1
RET
RNF114
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA4
RPS6KB1
RPTOR
RXRA
SCAND1
SCRIB
SMAD2
SNCG
SORBS3
SOS1
SOX2
SP1
SPIB
SRC
SREBF1
SREBF2
STAR
STAT3
STAT5A
STK11
STMN1
STMN2
STUB1
SULT4A1
SYK
SYN1
SYNE2
TAL1
TAL2
TCF3
TGIF1
TH
TNFSF11
TOP2B
TP53
TRIM54
TSC2
TTYH3
UBE4B
UBTF
USP21
VDR
VPS52
ZC3HC1
ZNF219
ZNF7
Entrez ID
1845
5595
HPRD ID
02553
03479
Ensembl ID
ENSG00000108861
ENSG00000102882
Uniprot IDs
P51452
L7RXH5
P27361
Q9BWJ1
PDB IDs
1J4X
1VHR
3F81
2ZOQ
4QTB
6GES
Enriched GO Terms of Interacting Partners
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