FGF7 and PTX3

Data Source:
BioGRID (pull down)

		FGF7	PTX3
Description		fibroblast growth factor 7	pentraxin 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus	Extracellular Region Extracellular Space Extracellular Matrix Specific Granule Lumen Tertiary Granule Lumen
	Molecular Function	Fibroblast Growth Factor Receptor Binding Type 2 Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity	Complement Component C1q Complex Binding (1->3)-beta-D-glucan Binding Protein Binding Identical Protein Binding Virion Binding
	Biological Process	MAPK Cascade Positive Regulation Of Protein Phosphorylation Signal Transduction Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Response To Wounding Animal Organ Morphogenesis Mesenchymal Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Keratinocyte Proliferation Cell Differentiation Lung Development Regulation Of Cell Migration Hair Follicle Morphogenesis Actin Cytoskeleton Reorganization Protein Localization To Cell Surface Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Keratinocyte Migration Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Branching Involved In Salivary Gland Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Secretion By Lung Epithelial Cell Involved In Lung Growth	Ovarian Cumulus Expansion Response To Yeast Inflammatory Response Opsonization Extracellular Matrix Organization Neutrophil Degranulation Negative Regulation By Host Of Viral Process Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Phagocytosis Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Glycoprotein Metabolic Process
Pathways		PI3K Cascade PIP3 activates AKT signaling FGFR2b ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR2 PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling Negative regulation of FGFR2 signaling Signaling by FGFR2 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Neutrophil degranulation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Lung adenocarcinoma ( 28604730) Thyroid hormone levels ( 23408906) Thyroid volume ( 21565293)	Body mass index ( 26426971)
Interacting Genes		14 interacting genes: COL1A1 COL2A1 COL3A1 COL6A1 DESI1 DUSP3 FGFR1 FGFR2 FGFR3 FGFR4 HSPG2 NRP1 PTX3 UBQLN1	15 interacting genes: C1QA C1QB C1QC CFH FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF5 FGF7 FGF8 MTNR1A
Entrez ID		2252	5806
HPRD ID		01022	03928
Ensembl ID		ENSG00000140285	ENSG00000163661
Uniprot IDs		P21781	P26022
PDB IDs
Enriched GO Terms of Interacting Partners?
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