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DUSP3 and SYK
Data Source:
HPRD
(in vitro, in vivo)
DUSP3
SYK
Description
dual specificity phosphatase 3
spleen associated tyrosine kinase
Image
GO Annotations
Cellular Component
Immunological Synapse
Nucleus
Nucleoplasm
Cytosol
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
B Cell Receptor Complex
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Early Phagosome
Protein-containing Complex
T Cell Receptor Complex
Molecular Function
Protein Tyrosine Phosphatase Activity
Protein Binding
Cytoskeletal Protein Binding
Protein Tyrosine/serine/threonine Phosphatase Activity
Phosphatase Activity
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
MAP Kinase Phosphatase Activity
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Protein Tyrosine Kinase Binding
Phosphotyrosine Residue Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Integrin Binding
Protein Binding
ATP Binding
Interleukin-15 Receptor Binding
Protein Kinase Binding
Phosphatase Binding
Toll-like Receptor Binding
SH2 Domain Binding
Biological Process
Inactivation Of MAPK Activity
Dephosphorylation
Negative Regulation Of Cell Migration
Peptidyl-tyrosine Dephosphorylation
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of MAPK Cascade
Positive Regulation Of Mitotic Cell Cycle
Negative Regulation Of JNK Cascade
Negative Regulation Of T Cell Receptor Signaling Pathway
Negative Regulation Of T Cell Activation
Negative Regulation Of Chemotaxis
Regulation Of Focal Adhesion Assembly
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Focal Adhesion Disassembly
Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity
Angiogenesis
Lymph Vessel Development
Positive Regulation Of Receptor Internalization
Stimulatory C-type Lectin Receptor Signaling Pathway
Adaptive Immune Response
Macrophage Activation Involved In Immune Response
Neutrophil Activation Involved In Immune Response
Leukocyte Activation Involved In Immune Response
Serotonin Secretion By Platelet
Protein Phosphorylation
Protein Import Into Nucleus
Leukocyte Cell-cell Adhesion
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Integrin-mediated Signaling Pathway
Activation Of JUN Kinase Activity
Animal Organ Morphogenesis
Regulation Of Platelet Activation
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Viral Process
Peptidyl-serine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Leukotriene Biosynthetic Process
Cell Differentiation
Platelet Activation
Neutrophil Chemotaxis
Positive Regulation Of Protein-containing Complex Assembly
Receptor Internalization
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-3 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Regulation Of Superoxide Anion Generation
Positive Regulation Of Superoxide Anion Generation
Positive Regulation Of Cell Adhesion Mediated By Integrin
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Interleukin-2-mediated Signaling Pathway
Interleukin-3-mediated Signaling Pathway
Defense Response To Bacterium
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Mast Cell Degranulation
Regulation Of Neutrophil Degranulation
Beta Selection
Innate Immune Response
Positive Regulation Of B Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Positive Regulation Of Bone Resorption
Positive Regulation Of Alpha-beta T Cell Differentiation
Positive Regulation Of Alpha-beta T Cell Proliferation
Blood Vessel Morphogenesis
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Phagocytosis
Positive Regulation Of Calcium-mediated Signaling
B Cell Receptor Signaling Pathway
Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Killing Of Cells Of Other Organism
Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Molecule Of Fungal Origin
Cellular Response To Low-density Lipoprotein Particle Stimulus
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Regulation Of Arachidonic Acid Secretion
Regulation Of Platelet Aggregation
Positive Regulation Of Cold-induced Thermogenesis
Pathways
ERKs are inactivated
GPVI-mediated activation cascade
GPVI-mediated activation cascade
FCGR activation
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
DAP12 signaling
Fc epsilon receptor (FCERI) signaling
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Integrin signaling
CLEC7A (Dectin-1) signaling
Dectin-2 family
Dectin-2 family
Interleukin-2 signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
FLT3 signaling through SRC family kinases
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Staurosporine
N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide
Tamatinib
2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide
2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide
Ellagic acid
Fostamatinib
Diseases
GWAS
Fractures (
30158200
)
HDL cholesterol (
25961943
27036123
)
Metabolite levels (
23823483
)
Triglycerides (
25961943
)
Alzheimer's disease (
30636644
)
Anti-saccade response (
29064472
)
Atrial fibrillation (
28416822
)
Chromosomal aberration frequency (total) (
31586183
)
Frontal pole volume (
31530798
)
Mean platelet volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Multiple sclerosis (
21833088
)
Multiple sclerosis and HDL levels (pleiotropy) (
26920376
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
27863252
)
Plateletcrit (
32888494
)
Type 2 diabetes (
22456796
)
Vascular dementia (
23480133
)
Interacting Genes
15 interacting genes:
APP
BNIP3L
CASK
EGF
EGFR
FGF7
MAP2K2
MAPK1
MAPK3
MEOX1
NEUROD1
PDGFA
STAT1
SYK
ZAP70
107 interacting genes:
APP
AR
BLNK
BTK
CALM1
CBL
CBLB
CD19
CD22
CD3E
CD72
CD79A
CD79B
COASY
CRKL
CSF2RB
CSF3R
CTTN
DBNL
DPP9
DUSP3
EGFR
EPOR
ERBB2
ERBB3
ERBB4
FCER1G
FCGR1A
FCGR2A
FCGR3A
FCRL3
FGR
FYN
GAB1
GAB2
GRB2
HCLS1
HDAC1
HDAC2
HDAC3
HDAC4
HDAC6
HDAC9
HGS
HNRNPU
IL15RA
IL2RB
ITGB2
JAK1
KIT
LAT
LAX1
LCK
LCP2
LYN
MAP4K1
MAPK3
MAPT
MET
MS4A2
NEDD4
NFAM1
PAG1
PIK3AP1
PIK3R1
PIK3R2
PLCG1
PLCG2
POU2AF1
PRKCA
PRKD1
PTK2
PTK2B
PTPN6
PXN
RASA1
RHOU
RPS10
RPS6KA1
RPS6KB1
RPS6KB2
SELPLG
SH2B2
SH2D2A
SH3BP2
SHC1
SIT1
SLA
SLC4A1
SNCA
SRC
STAT1
STAT3
STAT5A
TERF1
TLR4
TNFRSF1A
TRAF6
TRIM15
TUBA1A
TUBA4A
TYROBP
UBASH3B
UBB
USP25
VAV1
VAV2
Entrez ID
1845
6850
HPRD ID
02553
02514
Ensembl ID
ENSG00000108861
ENSG00000165025
Uniprot IDs
P51452
A0A024R244
A0A024R273
P43405
PDB IDs
1J4X
1VHR
3F81
1A81
1CSY
1CSZ
1XBA
1XBB
1XBC
3BUW
3EMG
3FQE
3FQH
3FQS
3SRV
3TUB
3TUC
3TUD
3VF8
3VF9
4DFL
4DFN
4F4P
4FL1
4FL2
4FL3
4FYN
4FYO
4FZ6
4FZ7
4GFG
4I0R
4I0S
4I0T
4PUZ
4PV0
4PX6
4RSS
4RX7
4RX8
4RX9
4WNM
4XG2
4XG3
4XG4
4XG6
4XG7
4XG8
4XG9
4YJO
4YJP
4YJQ
4YJR
4YJS
4YJT
4YJU
4YJV
5C26
5C27
5CXH
5CXZ
5CY3
5GHV
5LMA
5LMB
5T68
5TIU
5TR6
5TT7
5Y5T
5Y5U
6HM6
6HM7
6SSB
6VOV
Enriched GO Terms of Interacting Partners
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