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CLN8 and ARL6IP5
Data Source:
BioGRID
(two hybrid)
CLN8
ARL6IP5
Description
CLN8 transmembrane ER and ERGIC protein
ADP ribosylation factor like GTPase 6 interacting protein 5
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Mitochondrion
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment
Integral Component Of Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Presynapse
Endoplasmic Reticulum Membrane
Cytoskeleton
Plasma Membrane
Membrane
Integral Component Of Membrane
Molecular Function
Protein Binding
Ceramide Binding
Molecular_function
Protein Binding
Biological Process
Age-dependent Response To Oxidative Stress
Phospholipid Metabolic Process
Ceramide Metabolic Process
Lipid Transport
Mitochondrial Membrane Organization
Lysosome Organization
Nervous System Development
Visual Perception
Adult Walking Behavior
Cholesterol Metabolic Process
Associative Learning
Regulation Of Cell Size
Lipid Biosynthetic Process
Somatic Motor Neuron Differentiation
Protein Catabolic Process
Social Behavior
Negative Regulation Of Apoptotic Process
Cellular Protein Catabolic Process
Photoreceptor Cell Maintenance
Negative Regulation Of Proteolysis
Ceramide Biosynthetic Process
Musculoskeletal Movement
Neuromuscular Process Controlling Posture
Neuromuscular Process Controlling Balance
Glutamate Reuptake
Lipid Homeostasis
Retina Development In Camera-type Eye
Neurofilament Cytoskeleton Organization
Negative Regulation Of L-glutamate Import Across Plasma Membrane
Glutathione Metabolic Process
Learning Or Memory
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Negative Regulation Of Mitochondrial Membrane Potential
L-glutamate Transmembrane Transport
Positive Regulation Of Stress-activated MAPK Cascade
Neuron Death In Response To Oxidative Stress
Positive Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Transport
Protein Localization To Plasma Membrane
L-glutamate Import Across Plasma Membrane
Pathways
Glutamate Neurotransmitter Release Cycle
Drugs
Diseases
Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS
Eye morphology (
29921221
)
Gaucher disease severity (
22388998
)
Systolic blood pressure (
30224653
)
Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes (
28736931
)
Urate levels (
31578528
)
Interacting Genes
30 interacting genes:
ARL6IP5
BNIP3
BNIP3L
CD9
CYB5B
ERG28
FZD7
GABARAPL2
GPM6B
MTX1
NDRG2
PDIA6
PLP1
PLP2
PTPRN
RRP15
RTN4
SELENOK
SPCS2
STX8
TMEM107
TMEM11
TMEM128
TMEM134
TMEM147
TMEM14A
TUBB4A
UBC
YIPF6
ZUP1
9 interacting genes:
ARL6
CCR2
CCR5
CLN8
KRAS
NOTCH1
PRAF2
SLC1A1
VKORC1
Entrez ID
2055
10550
HPRD ID
06383
09303
Ensembl ID
ENSG00000182372
ENSG00000144746
Uniprot IDs
A0A024QZ57
Q9UBY8
A0A024R371
O75915
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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