ARL6IP5 and CCR5

Data Source:
HPRD (in vivo)

		ARL6IP5	CCR5
Description		ADP ribosylation factor like GTPase 6 interacting protein 5	C-C motif chemokine receptor 5
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Membrane Integral Component Of Membrane	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface
	Molecular Function	Molecular_function Protein Binding	Virus Receptor Activity Actin Binding Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding Identical Protein Binding Chemokine (C-C Motif) Ligand 5 Binding
	Biological Process	Negative Regulation Of L-glutamate Import Across Plasma Membrane Glutathione Metabolic Process Learning Or Memory Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Negative Regulation Of Mitochondrial Membrane Potential L-glutamate Transmembrane Transport Positive Regulation Of Stress-activated MAPK Cascade Neuron Death In Response To Oxidative Stress Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transport Protein Localization To Plasma Membrane L-glutamate Import Across Plasma Membrane	MAPK Cascade Dendritic Cell Chemotaxis Calcium Ion Transport Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Fusion Of Virus Membrane With Host Plasma Membrane Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway Response To Cholesterol Cellular Response To Lipopolysaccharide
Pathways		Glutamate Neurotransmitter Release Cycle	Binding and entry of HIV virion Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs			Maraviroc AMD-070 CCR5 mAb Leronlimab Aplaviroc Vicriviroc Ibalizumab INCB-9471
Diseases
GWAS		Urate levels ( 31578528)	Blood protein levels ( 28240269) Blood protein levels in cardiovascular risk ( 28369058) Celiac disease ( 20190752) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 26192919) Type 1 diabetes ( 25751624) Ulcerative colitis ( 26192919 28067908)
Interacting Genes		9 interacting genes: ARL6 CCR2 CCR5 CLN8 KRAS NOTCH1 PRAF2 SLC1A1 VKORC1	43 interacting genes: AFP ARL6IP5 ARRB1 CCL11 CCL13 CCL14 CCL16 CCL2 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCL8 CD4 CST9L CTBP2 CXCR4 DNM2 EMP1 ETV5 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GRK2 GRK3 IL24 JAK1 JAK2 LCK ORM1 PRAF2 PSMA5 PTK2 PTK2B SLC20A2 STAT1 STAT3 STAT5A TXK
Entrez ID		10550	1234
HPRD ID		09303	03223
Ensembl ID		ENSG00000144746	ENSG00000160791
Uniprot IDs		A0A024R371 O75915	P51681 Q38L21
PDB IDs			1ND8 1NE0 1OPN 1OPT 1OPW 2L87 2MZX 2RLL 2RRS 4MBS 5UIW 5YD3 5YD4 5YD5 5YY4 6FGP 6MEO 6MET
Enriched GO Terms of Interacting Partners?
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