ARL6IP5 and CLN8

Data Source:
BioGRID (two hybrid)

		ARL6IP5	CLN8
Description		ADP ribosylation factor like GTPase 6 interacting protein 5	CLN8 transmembrane ER and ERGIC protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Membrane Integral Component Of Membrane	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Presynapse
	Molecular Function	Molecular_function Protein Binding	Protein Binding Ceramide Binding
	Biological Process	Negative Regulation Of L-glutamate Import Across Plasma Membrane Glutathione Metabolic Process Learning Or Memory Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Negative Regulation Of Mitochondrial Membrane Potential L-glutamate Transmembrane Transport Positive Regulation Of Stress-activated MAPK Cascade Neuron Death In Response To Oxidative Stress Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transport Protein Localization To Plasma Membrane L-glutamate Import Across Plasma Membrane	Age-dependent Response To Oxidative Stress Phospholipid Metabolic Process Ceramide Metabolic Process Lipid Transport Mitochondrial Membrane Organization Lysosome Organization Nervous System Development Visual Perception Adult Walking Behavior Cholesterol Metabolic Process Associative Learning Regulation Of Cell Size Lipid Biosynthetic Process Somatic Motor Neuron Differentiation Protein Catabolic Process Social Behavior Negative Regulation Of Apoptotic Process Cellular Protein Catabolic Process Photoreceptor Cell Maintenance Negative Regulation Of Proteolysis Ceramide Biosynthetic Process Musculoskeletal Movement Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Glutamate Reuptake Lipid Homeostasis Retina Development In Camera-type Eye Neurofilament Cytoskeleton Organization
Pathways		Glutamate Neurotransmitter Release Cycle
Drugs
Diseases			Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Urate levels ( 31578528)	Eye morphology ( 29921221) Gaucher disease severity ( 22388998) Systolic blood pressure ( 30224653) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		9 interacting genes: ARL6 CCR2 CCR5 CLN8 KRAS NOTCH1 PRAF2 SLC1A1 VKORC1	30 interacting genes: ARL6IP5 BNIP3 BNIP3L CD9 CYB5B ERG28 FZD7 GABARAPL2 GPM6B MTX1 NDRG2 PDIA6 PLP1 PLP2 PTPRN RRP15 RTN4 SELENOK SPCS2 STX8 TMEM107 TMEM11 TMEM128 TMEM134 TMEM147 TMEM14A TUBB4A UBC YIPF6 ZUP1
Entrez ID		10550	2055
HPRD ID		09303	06383
Ensembl ID		ENSG00000144746	ENSG00000182372
Uniprot IDs		A0A024R371 O75915	A0A024QZ57 Q9UBY8
PDB IDs
Enriched GO Terms of Interacting Partners?
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