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CLN8 and RTN4
Data Source:
BioGRID
(two hybrid)
CLN8
RTN4
Description
CLN8 transmembrane ER and ERGIC protein
reticulon 4
Image
No pdb structure
GO Annotations
Cellular Component
Mitochondrion
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment
Integral Component Of Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Presynapse
Nuclear Envelope
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Plasma Membrane
Postsynaptic Density
Integral Component Of Endoplasmic Reticulum Membrane
Cell Projection
Neuronal Cell Body
Endoplasmic Reticulum Tubular Network
Endoplasmic Reticulum Tubular Network Membrane
Molecular Function
Protein Binding
Ceramide Binding
RNA Binding
Protein Binding
Ubiquitin Protein Ligase Binding
Cadherin Binding
Biological Process
Age-dependent Response To Oxidative Stress
Phospholipid Metabolic Process
Ceramide Metabolic Process
Lipid Transport
Mitochondrial Membrane Organization
Lysosome Organization
Nervous System Development
Visual Perception
Adult Walking Behavior
Cholesterol Metabolic Process
Associative Learning
Regulation Of Cell Size
Lipid Biosynthetic Process
Somatic Motor Neuron Differentiation
Protein Catabolic Process
Social Behavior
Negative Regulation Of Apoptotic Process
Cellular Protein Catabolic Process
Photoreceptor Cell Maintenance
Negative Regulation Of Proteolysis
Ceramide Biosynthetic Process
Musculoskeletal Movement
Neuromuscular Process Controlling Posture
Neuromuscular Process Controlling Balance
Glutamate Reuptake
Lipid Homeostasis
Retina Development In Camera-type Eye
Neurofilament Cytoskeleton Organization
Blastocyst Formation
Apoptotic Process
Axonal Fasciculation
Positive Regulation Of Epithelial Cell Migration
Cerebral Cortex Radial Glia Guided Migration
Negative Regulation Of Cell Growth
Negative Regulation Of Axon Extension
Positive Regulation Of Mammary Gland Epithelial Cell Proliferation
Positive Regulation Of Toll-like Receptor 9 Signaling Pathway
Regulation Of Apoptotic Process
Negative Regulation Of Axonogenesis
Protein Stabilization
Nuclear Pore Complex Assembly
Positive Regulation Of Protein Kinase B Signaling
Cardiac Epithelial To Mesenchymal Transition
Protein Localization To Lysosome
Endoplasmic Reticulum Tubular Network Organization
Endoplasmic Reticulum Tubular Network Formation
Cellular Sphingolipid Homeostasis
Negative Regulation Of Amyloid-beta Formation
Positive Regulation Of Protein Localization To Endoplasmic Reticulum
Positive Regulation Of ERBB3 Signaling Pathway
Endoplasmic Reticulum Tubular Network Membrane Organization
Regulation Of Branching Morphogenesis Of A Nerve
Pathways
Axonal growth inhibition (RHOA activation)
Drugs
Diseases
Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS
Eye morphology (
29921221
)
Gaucher disease severity (
22388998
)
Systolic blood pressure (
30224653
)
Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes (
28736931
)
Adult body size (
32376654
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Obesity (extreme) (
19553259
)
Platelet count (
32888494
)
Systolic blood pressure (
30224653
)
Interacting Genes
30 interacting genes:
ARL6IP5
BNIP3
BNIP3L
CD9
CYB5B
ERG28
FZD7
GABARAPL2
GPM6B
MTX1
NDRG2
PDIA6
PLP1
PLP2
PTPRN
RRP15
RTN4
SELENOK
SPCS2
STX8
TMEM107
TMEM11
TMEM128
TMEM134
TMEM147
TMEM14A
TUBB4A
UBC
YIPF6
ZUP1
47 interacting genes:
BAIAP2
BCL2
BCL2L1
BDKRB1
CCR4
CERT1
CHRM4
CLN8
CNTNAP1
CRMP1
CYSLTR2
DRD2
ERBB2
ERBB3
ERBB4
F2RL1
FXR2
GLP1R
GPR35
HLA-DPB1
HTR2C
LAMA4
LINC01554
LMNA
LRCH4
LRPAP1
MBP
NAPA
NR4A1
PLEKHF2
POT1
PRR13
RAB33A
RPS27
RTN3
RTN4IP1
RTN4R
SNX1
SNX15
SPG21
SYT16
TERF1
TUBA4A
UQCRC1
UQCRC2
WWP1
ZFYVE21
Entrez ID
2055
57142
HPRD ID
06383
07259
Ensembl ID
ENSG00000182372
ENSG00000115310
Uniprot IDs
A0A024QZ57
Q9UBY8
Q9NQC3
PDB IDs
2G31
2JV5
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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