EIF4G2 and EIF4A1

Data Source:
HPRD (in vitro, in vivo)

		EIF4G2	EIF4A1
Description		eukaryotic translation initiation factor 4 gamma 2	eukaryotic translation initiation factor 4A1
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GO Annotations	Cellular Component	Cytosol Adherens Junction Membrane Eukaryotic Translation Initiation Factor 4F Complex Axon	Nucleus Cytoplasm Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Extracellular Exosome
	Molecular Function	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Cadherin Binding	RNA Cap Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding
	Biological Process	Translational Initiation Regulation Of Translational Initiation Cell Cycle Arrest Heart Development Cell Death Negative Regulation Of Autophagy Positive Regulation Of Cell Growth Cellular Macromolecule Biosynthetic Process Positive Regulation Of Translation Positive Regulation Of Axon Extension Positive Regulation Of Dendritic Spine Development	Cytoplasmic Translational Initiation Translational Initiation Viral Process
Pathways		ISG15 antiviral mechanism	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs			Copper
Diseases
GWAS		Metabolite levels ( 23823483)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		13 interacting genes: C1QTNF9 CASP3 EIF2S2 EIF3A EIF4A1 EIF4A2 EIF4E EIF5 MKNK1 NCBP1 RPA2 SKIL SUMO2	13 interacting genes: EIF4G1 EIF4G2 EIF4G3 FAM107A LIG4 MAPK6 PAIP1 PLPPR4 PRMT1 SUMO2 TNKS UCHL5 UPF2
Entrez ID		1982	1973
HPRD ID		09084	04030
Ensembl ID		ENSG00000110321	ENSG00000161960
Uniprot IDs		P78344 Q2TU89	P60842
PDB IDs		3D3M 3L6A 4IUL	2G9N 2ZU6 3EIQ 5ZBZ 5ZC9 6ZMW
Enriched GO Terms of Interacting Partners?
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