EIF4G2 and MKNK1

Data Source:
HPRD (in vitro, in vivo)

		EIF4G2	MKNK1
Description		eukaryotic translation initiation factor 4 gamma 2	MAPK interacting serine/threonine kinase 1
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GO Annotations	Cellular Component	Cytosol Adherens Junction Membrane Eukaryotic Translation Initiation Factor 4F Complex Axon	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Cadherin Binding	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Translational Initiation Regulation Of Translational Initiation Cell Cycle Arrest Heart Development Cell Death Negative Regulation Of Autophagy Positive Regulation Of Cell Growth Cellular Macromolecule Biosynthetic Process Positive Regulation Of Translation Positive Regulation Of Axon Extension Positive Regulation Of Dendritic Spine Development	Regulation Of Translation Protein Phosphorylation Peptidyl-serine Phosphorylation Intracellular Signal Transduction Protein Autophosphorylation
Pathways		ISG15 antiviral mechanism	Spry regulation of FGF signaling
Drugs			Fostamatinib
Diseases
GWAS		Metabolite levels ( 23823483)	Schizophrenia ( 26198764) Triglyceride levels ( 31170924)
Interacting Genes		13 interacting genes: C1QTNF9 CASP3 EIF2S2 EIF3A EIF4A1 EIF4A2 EIF4E EIF5 MKNK1 NCBP1 RPA2 SKIL SUMO2	26 interacting genes: APP ATXN3 CREBBP CREM DDAH2 DNAJC7 EIF4E EIF4G1 EIF4G2 EIF4G3 FANCA HGS HIPK2 HSP90AB1 MAPK1 MAPK14 MAPK3 MBP PAK2 PHAX PLA2G4A PRKDC RCN3 SPRY2 TNIP2 UBE2D1
Entrez ID		1982	8569
HPRD ID		09084	09468
Ensembl ID		ENSG00000110321	ENSG00000079277
Uniprot IDs		P78344 Q2TU89	A8K341 Q7Z319 Q9BUB5
PDB IDs		3D3M 3L6A 4IUL	2HW6 2Y9Q 5WVD
Enriched GO Terms of Interacting Partners?
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