EIF4G2 and EIF5

Data Source:
HPRD (in vitro)

		EIF4G2	EIF5
Description		eukaryotic translation initiation factor 4 gamma 2	eukaryotic translation initiation factor 5
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GO Annotations	Cellular Component	Cytosol Adherens Junction Membrane Eukaryotic Translation Initiation Factor 4F Complex Axon	Nucleus Cytoplasm Cytosol Plasma Membrane
	Molecular Function	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Cadherin Binding	RNA Binding Translation Initiation Factor Activity GDP-dissociation Inhibitor Activity Protein Binding GTP Binding Cadherin Binding Eukaryotic Initiation Factor EIF2 Binding
	Biological Process	Translational Initiation Regulation Of Translational Initiation Cell Cycle Arrest Heart Development Cell Death Negative Regulation Of Autophagy Positive Regulation Of Cell Growth Cellular Macromolecule Biosynthetic Process Positive Regulation Of Translation Positive Regulation Of Axon Extension Positive Regulation Of Dendritic Spine Development	Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Regulation Of Translational Initiation Activation Of GTPase Activity
Pathways		ISG15 antiviral mechanism	Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Monocyte count ( 29403010) Number of sexual partners ( 30643258) Red blood cell traits ( 23222517)
Interacting Genes		13 interacting genes: C1QTNF9 CASP3 EIF2S2 EIF3A EIF4A1 EIF4A2 EIF4E EIF5 MKNK1 NCBP1 RPA2 SKIL SUMO2	16 interacting genes: APP CDC42 CSNK2A1 CSNK2B DUSP12 EIF1AX EIF1AY EIF2S2 EIF3D EIF3G EIF4G1 EIF4G2 HSPB1 NCBP2 NRGN PUM1
Entrez ID		1982	1983
HPRD ID		09084	03417
Ensembl ID		ENSG00000110321	ENSG00000100664
Uniprot IDs		P78344 Q2TU89	A0A024R6Q1 P55010
PDB IDs		3D3M 3L6A 4IUL	2E9H 2G2K 2IU1
Enriched GO Terms of Interacting Partners?
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