UBE2A and RNF20

Data Source:
BioGRID (enzymatic study, affinity chromatography technology, affinity chromatography technology)

		UBE2A	RNF20
Description		ubiquitin conjugating enzyme E2 A	ring finger protein 20
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GO Annotations	Cellular Component	Chromatin XY Body Nucleoplasm Cytosol HULC Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Nucleolus HULC Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	P53 Binding Chromatin Binding Transcription Coactivator Activity MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Blastocyst Hatching DNA Repair Postreplication Repair Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Population Proliferation Response To UV Protein Ubiquitination Histone Ubiquitination Histone H2A Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Maternal Process Involved In Female Pregnancy Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Protein Polyubiquitination Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Histone Monoubiquitination Protein Ubiquitination Negative Regulation Of Cell Migration Positive Regulation Of Histone Methylation Histone H2B Ubiquitination Positive Regulation Of Transcription, DNA-templated Negative Regulation Of MRNA Polyadenylation Positive Regulation Of Histone H2B Ubiquitination
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation	E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Brain connectivity ( 23471985)
Interacting Genes		26 interacting genes: CBX5 CDK1 CDK2 CDK9 CDKN2A CRMP1 EEF1D H2BC21 HLTF KCMF1 MDM2 PCNA PRKN RAD18 RC3H1 RNF20 RNF4 RNF40 SDCBP TP53 TRIM27 UBA1 UBR1 UBR3 UBR5 ZMYM2	36 interacting genes: AMOTL2 ATM BAG4 C1orf109 CDC73 FBXO7 FGFR4 H2AC18 H2AC20 H2BC21 H2BC3 H3C14 H4C14 HSF1 HTT ITSN2 KIF11 MSL1 NCBP1 PA2G4 PAF1 PRPF8 RB1CC1 RNF40 SMURF2 SUMO2 TACC3 TRIM14 UBE2A UBE2B UBE2D2 UBE2E1 UBE2L3 USHBP1 XRCC3 ZDHHC17
Entrez ID		7319	56254
HPRD ID		02422	07410
Ensembl ID		ENSG00000077721	ENSG00000155827
Uniprot IDs		A0A0D9SG71 P49459	Q5VTR2
PDB IDs		6CYO 6CYR	5TRB
Enriched GO Terms of Interacting Partners?
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