Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
AGTR1 and AP2M1
Data Source:
BioGRID
(two hybrid)
AGTR1
AP2M1
Description
angiotensin II receptor type 1
adaptor related protein complex 2 subunit mu 1
Image
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Integral Component Of Membrane
Lysosomal Membrane
Cytosol
Plasma Membrane
Clathrin-coated Pit
AP-2 Adaptor Complex
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Cytoplasmic Vesicle
Endolysosome Membrane
Intracellular Membrane-bounded Organelle
Clathrin-coated Endocytic Vesicle
Extracellular Exosome
Molecular Function
Angiotensin Type I Receptor Activity
G Protein-coupled Receptor Activity
Angiotensin Type II Receptor Activity
Protein Binding
Bradykinin Receptor Binding
Protein Heterodimerization Activity
Signal Sequence Binding
Protein Binding
Lipid Binding
Clathrin Adaptor Activity
Ion Channel Binding
Low-density Lipoprotein Particle Receptor Binding
Biological Process
Regulation Of Cell Growth
Kidney Development
Renin-angiotensin Regulation Of Aldosterone Production
Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin
Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin
Inflammatory Response
G Protein-coupled Receptor Signaling Pathway
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Rho Protein Signal Transduction
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cholesterol Esterification
Regulation Of Vasoconstriction
Calcium-mediated Signaling
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Phospholipase A2 Activity
Positive Regulation Of NAD(P)H Oxidase Activity
Low-density Lipoprotein Particle Remodeling
Regulation Of Renal Sodium Excretion
Angiotensin-activated Signaling Pathway
Regulation Of Cell Population Proliferation
Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway
Cell Chemotaxis
Phospholipase C-activating Angiotensin-activated Signaling Pathway
Blood Vessel Diameter Maintenance
Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Intracellular Protein Transport
Endocytosis
Vesicle Budding From Membrane
Vesicle-mediated Transport
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Receptor Internalization
Low-density Lipoprotein Particle Receptor Catabolic Process
Low-density Lipoprotein Particle Clearance
Cellular Protein-containing Complex Assembly
Ephrin Receptor Signaling Pathway
Regulation Of Defense Response To Virus By Virus
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Membrane Organization
Clathrin-dependent Endocytosis
Regulation Of Vesicle Size
Negative Regulation Of Protein Localization To Plasma Membrane
Pathways
Peptide ligand-binding receptors
G alpha (q) signalling events
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Nef mediated downregulation of CD28 cell surface expression
Nef Mediated CD4 Down-regulation
Retrograde neurotrophin signalling
Retrograde neurotrophin signalling
Nef Mediated CD8 Down-regulation
Gap junction degradation
Formation of annular gap junctions
MHC class II antigen presentation
EPH-ephrin mediated repulsion of cells
Recycling pathway of L1
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance
Potential therapeutics for SARS
Drugs
Valsartan
Olmesartan
Losartan
Candesartan cilexetil
Eprosartan
Telmisartan
Irbesartan
Forasartan
Saprisartan
Tasosartan
CYT006-AngQb
Azilsartan medoxomil
Fimasartan
Angiotensin II
Candesartan
Diseases
Renal tubular dysgenesis
GWAS
Birth weight (
31043758
)
Chin dimples (
27182965
)
Height (
31562340
)
Lead levels in blood (
25820613
)
Monobrow (
27182965
)
Type 2 diabetes (
31049640
)
Major depressive disorder (
22472876
)
Interacting Genes
76 interacting genes:
ABI3
ADD3
AGT
AGTRAP
AP2M1
ARFGAP1
ARHGDIG
ARRB1
ARRB2
ATP13A1
ATP1B1
BAALC
BASP1
BDKRB2
BNIP3
BRD8
CBR1
CCDC25
CD37
CERS6
CUEDC2
DBNDD2
DNAJC14
DNAJC8
EGFR
FAM13B
FBXW11
FNBP1
GHITM
GNA12
GOT1
GPAA1
GPRASP1
GRK2
GRK3
GRK5
HDGFL2
HHATL
HRAS
JAK1
JAK2
JKAMP
KIAA0930
LCNL1
LLGL1
LZTS1
NACAD
NDRG2
NOS3
NPTN
NUP88
OAZ1
PCMT1
PDE6H
PLCG1
PLCH2
PNMA1
PPP1R3F
PSMD10
PTGFR
RAB5A
RAF1
RBSN
RTN3
SAE1
SCG5
SELENOF
SERINC3
SLC16A1
SPG21
THOP1
TMEM161A
TMEM80
UBR4
UGT8
YWHAQ
76 interacting genes:
ADRA1B
AGTR1
AP2B1
AQP4
ARRB2
ATXN1L
BDKRB2
C1orf35
CACNA1A
CD22
CD3D
CDK11B
CORO7
CSNK2B
CTLA4
CXorf51A
CXorf51B
DAB2
DCX
DPPA2
DVL2
EAF1
EHD2
EIF1AD
FAM90A1
FURIN
FXR2
GAK
GRIN2B
H2BC10
H2BC13
H2BC21
H2BC4
H2BC6
H2BC7
H2BC8
HEXIM2
HTR6
IKZF1
KCNJ11
KNOP1
LAMP1
LTB4R2
LY9
MAB21L3
MED4
MEGF10
MFAP1
MPP1
MTURN
NAA11
NCOR2
NDRG1
NKAPD1
PRPF18
PRPF38A
PRR13
PTS
RALBP1
RNF111
RPL22
RPL38
RRP12
RSPH14
RUNDC3A
SFRP4
STON2
SYNJ1
TASOR
TBC1D5
TGOLN2
TMA16
UBC
UTP25
ZBTB8A
ZNF581
Entrez ID
185
1173
HPRD ID
00107
03014
Ensembl ID
ENSG00000144891
ENSG00000161203
Uniprot IDs
A0A0A0MSE3
D3DNG8
P30556
Q53YY0
Q6NUP5
B4DNB9
E9PFW3
Q96CW1
PDB IDs
1ZV0
4YAY
4ZUD
6DO1
6OS0
6OS1
6OS2
1H6E
6BNT
6URI
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?