AGTR1 and NOS3

Data Source:
HPRD (in vitro)

		AGTR1	NOS3
Description		angiotensin II receptor type 1	nitric oxide synthase 3
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Golgi Membrane Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Caveola Vesicle Membrane Endocytic Vesicle Membrane
	Molecular Function	Angiotensin Type I Receptor Activity G Protein-coupled Receptor Activity Angiotensin Type II Receptor Activity Protein Binding Bradykinin Receptor Binding Protein Heterodimerization Activity	Actin Monomer Binding Nitric-oxide Synthase Activity Protein Binding Calmodulin Binding FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Tetrahydrobiopterin Binding Arginine Binding Cadmium Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding
	Biological Process	Regulation Of Cell Growth Kidney Development Renin-angiotensin Regulation Of Aldosterone Production Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Inflammatory Response G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Esterification Regulation Of Vasoconstriction Calcium-mediated Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phospholipase A2 Activity Positive Regulation Of NAD(P)H Oxidase Activity Low-density Lipoprotein Particle Remodeling Regulation Of Renal Sodium Excretion Angiotensin-activated Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Cell Chemotaxis Phospholipase C-activating Angiotensin-activated Signaling Pathway Blood Vessel Diameter Maintenance Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Reactive Oxygen Species Metabolic Process	Blood Vessel Remodeling Regulation Of Systemic Arterial Blood Pressure By Endothelin Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Morphogenesis Arginine Catabolic Process Nitric Oxide Biosynthetic Process Mitochondrion Organization Nitric Oxide Mediated Signal Transduction Regulation Of Blood Pressure Negative Regulation Of Cell Population Proliferation Response To Heat Response To Hormone Negative Regulation Of Platelet Activation Positive Regulation Of Gene Expression Negative Regulation Of Muscle Hyperplasia Smooth Muscle Hyperplasia Removal Of Superoxide Radicals Positive Regulation Of Guanylate Cyclase Activity Regulation Of Nervous System Process Response To Lipopolysaccharide Response To Fluid Shear Stress Vasodilation Positive Regulation Of Blood Vessel Endothelial Cell Migration Endothelial Cell Migration Cell Redox Homeostasis Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Negative Regulation Of Blood Pressure Homeostasis Of Number Of Cells Within A Tissue Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Biomineral Tissue Development Blood Vessel Diameter Maintenance Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	ROS and RNS production in phagocytes Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation eNOS activation NOSTRIN mediated eNOS trafficking NOSIP mediated eNOS trafficking Nitric oxide stimulates guanylate cyclase VEGFR2 mediated vascular permeability Extra-nuclear estrogen signaling
Drugs		Valsartan Olmesartan Losartan Candesartan cilexetil Eprosartan Telmisartan Irbesartan Forasartan Saprisartan Tasosartan CYT006-AngQb Azilsartan medoxomil Fimasartan Angiotensin II Candesartan	Arginine Citrulline Sapropterin Miconazole N,N-dimethylarginine L-N(omega)-Nitroarginine-2,4-L-diaminobutyric amide Canavanine 3-Bromo-7-Nitroindazole N-{(4S)-4-Amino-5-[(2-aminoethyl)amino]pentyl}-N'-nitroguanidine N-[3-(aminomethyl)benzyl]acetamidine 1,2,4-Triazole-Carboxamidine L-N(omega)-nitroarginine-(4R)-amino-L-proline amide S,S'-(1,4-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea 7-Nitroindazole S-Ethylisothiourea 2-Aminothiazoline Se-Ethyl-Isoselenourea 2,4-Diamino-6-Phenyl-5,6,7,8,-Tetrahydropteridine N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane Cacodylic acid 7-Nitroindazole-2-Carboxamidine 6-Nitroindazole N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine N(G)-Iminoethylornithine 5,6-Cyclic-Tetrahydropteridine S-Ethyl-N-Phenyl-Isothiourea S,S'-(1,3-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea 6S-5,6,7,8-Tetrahydrobiopterin S-(Dimethylarsenic)Cysteine L-homoarginine S-Isopropyl-Isothiourea Nitroarginine 5-Nitroindazole N-(Chlorophenyl)-N'-hydroxyguanidine (3S,5E)-3-propyl-3,4-dihydrothieno[2,3-f][1,4]oxazepin-5(2H)-imine 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine Levamlodipine
Diseases		Renal tubular dysgenesis
GWAS		Birth weight ( 31043758) Chin dimples ( 27182965) Height ( 31562340) Lead levels in blood ( 25820613) Monobrow ( 27182965) Type 2 diabetes ( 31049640)	Coronary artery disease ( 29212778 30104761 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878 28739976 27618448) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Estimated glomerular filtration rate ( 31451708) Eyebrow thickness ( 26926045) Hypertension ( 27618448) Mean arterial pressure ( 27618448) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Offspring birth weight ( 31043758) Periventricular white matter hyperintensities ( 32517579) Platelet distribution width ( 32888494) Stroke ( 30383316) Systolic blood pressure ( 27841878 27618448 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		76 interacting genes: ABI3 ADD3 AGT AGTRAP AP2M1 ARFGAP1 ARHGDIG ARRB1 ARRB2 ATP13A1 ATP1B1 BAALC BASP1 BDKRB2 BNIP3 BRD8 CBR1 CCDC25 CD37 CERS6 CUEDC2 DBNDD2 DNAJC14 DNAJC8 EGFR FAM13B FBXW11 FNBP1 GHITM GNA12 GOT1 GPAA1 GPRASP1 GRK2 GRK3 GRK5 HDGFL2 HHATL HRAS JAK1 JAK2 JKAMP KIAA0930 LCNL1 LLGL1 LZTS1 NACAD NDRG2 NOS3 NPTN NUP88 OAZ1 PCMT1 PDE6H PLCG1 PLCH2 PNMA1 PPP1R3F PSMD10 PTGFR RAB5A RAF1 RBSN RTN3 SAE1 SCG5 SELENOF SERINC3 SLC16A1 SPG21 THOP1 TMEM161A TMEM80 UBR4 UGT8 YWHAQ	47 interacting genes: A2M ACTN2 ACTN4 AGTR1 AKT1 APOE APP BDKRB2 BDNF CALM1 CAV1 CDC37 CEP55 EDNRB EFEMP1 EFEMP2 ELAVL1 ELAVL3 EXOC6 EXOSC1 FIS1 GCDH GOLGA2 H3-3A HSP90AA1 HTRA1 IKZF3 IMMT KANK2 MAGEA11 MAST1 MPRIP NMT1 NOSIP NOSTRIN PAXIP1 PI4K2A PPP2R5A PSEN1 PSEN2 RNF31 RNF32 SP1 ST13 TECR TXNDC11 UMPS
Entrez ID		185	4846
HPRD ID		00107	01224
Ensembl ID		ENSG00000144891	ENSG00000164867
Uniprot IDs		A0A0A0MSE3 D3DNG8 P30556 Q53YY0 Q6NUP5	A0S0A6 P29474
PDB IDs		1ZV0 4YAY 4ZUD 6DO1 6OS0 6OS1 6OS2	1M9J 1M9K 1M9M 1M9Q 1M9R 1NIW 2LL7 2MG5 2N8J 3EAH 3NOS 4D1O 4D1P 5UO8 5UO9 5UOA 5UOB 5UOC 5VVB 5VVC 5VVD 5XOF 6AV6 6AV7 6CIE 6CIF 6NH1 6NH2 6NH3 6NH4 6NH5 6NH6 6NH7 6NH8 6NHF 6POU 6POV 6POW 6POX 6POY 6POZ 6PP0 6PP1 6PP2 6PP3 6PP4
Enriched GO Terms of Interacting Partners?
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