AP2M1 and GAK

Data Source:
HPRD (in vitro)

		AP2M1	GAK
Description		adaptor related protein complex 2 subunit mu 1	cyclin G associated kinase
Image
GO Annotations	Cellular Component	Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Intracellular Membrane-bounded Organelle Clathrin-coated Endocytic Vesicle Extracellular Exosome	Cytoplasm Golgi Apparatus Cytosol Focal Adhesion Membrane Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Presynapse
	Molecular Function	Signal Sequence Binding Protein Binding Lipid Binding Clathrin Adaptor Activity Ion Channel Binding Low-density Lipoprotein Particle Receptor Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Clathrin Binding Cyclin Binding Chaperone Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Intracellular Protein Transport Endocytosis Vesicle Budding From Membrane Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Internalization Low-density Lipoprotein Particle Receptor Catabolic Process Low-density Lipoprotein Particle Clearance Cellular Protein-containing Complex Assembly Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Organization Clathrin-dependent Endocytosis Regulation Of Vesicle Size Negative Regulation Of Protein Localization To Plasma Membrane	Protein Phosphorylation Receptor-mediated Endocytosis Endoplasmic Reticulum Organization Golgi Organization Cell Cycle Negative Regulation Of Neuron Projection Development Synaptic Vesicle Uncoating Protein Localization To Golgi Apparatus Chaperone Cofactor-dependent Protein Refolding Membrane Organization Clathrin Coat Disassembly Clathrin-dependent Endocytosis Protein Localization To Plasma Membrane Golgi To Lysosome Transport Clathrin-coated Pit Assembly
Pathways		Nef mediated downregulation of CD28 cell surface expression Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS	Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
Drugs			Fostamatinib
Diseases
GWAS		Major depressive disorder ( 22472876)	HDL cholesterol ( 30275531) Mortality in sepsis ( 27639821) Parkinson's disease ( 20711177 21292315 25064009 27182965 22438815 21738487 32310270) Parkinson's disease (age of onset) ( 30957308) Parkinson's disease (familial) ( 18985386) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Primary biliary cholangitis ( 26394269) Triglycerides ( 30275531)
Interacting Genes		76 interacting genes: ADRA1B AGTR1 AP2B1 AQP4 ARRB2 ATXN1L BDKRB2 C1orf35 CACNA1A CD22 CD3D CDK11B CORO7 CSNK2B CTLA4 CXorf51A CXorf51B DAB2 DCX DPPA2 DVL2 EAF1 EHD2 EIF1AD FAM90A1 FURIN FXR2 GAK GRIN2B H2BC10 H2BC13 H2BC21 H2BC4 H2BC6 H2BC7 H2BC8 HEXIM2 HTR6 IKZF1 KCNJ11 KNOP1 LAMP1 LTB4R2 LY9 MAB21L3 MED4 MEGF10 MFAP1 MPP1 MTURN NAA11 NCOR2 NDRG1 NKAPD1 PRPF18 PRPF38A PRR13 PTS RALBP1 RNF111 RPL22 RPL38 RRP12 RSPH14 RUNDC3A SFRP4 STON2 SYNJ1 TASOR TBC1D5 TGOLN2 TMA16 UBC UTP25 ZBTB8A ZNF581	14 interacting genes: AP1M1 AP1M2 AP2M1 APP AR AXIN1 CCNG1 CDK5 CLTC CREBBP HSPA8 LRRK1 MFHAS1 USO1
Entrez ID		1173	2580
HPRD ID		03014	03631
Ensembl ID		ENSG00000161203	ENSG00000178950
Uniprot IDs		B4DNB9 E9PFW3 Q96CW1	B4DS37 O14976
PDB IDs		1H6E 6BNT 6URI	4C57 4C58 4C59 4O38 4Y8D 5Y7Z 5Y80
Enriched GO Terms of Interacting Partners?
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