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AGTR1 and NPTN
Data Source:
BioGRID
(two hybrid)
AGTR1
NPTN
Description
angiotensin II receptor type 1
neuroplastin
Image
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Integral Component Of Membrane
Immunological Synapse
Plasma Membrane
Cell Surface
Axon
Dendrite
Presynaptic Membrane
Inhibitory Synapse
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
GABA-ergic Synapse
Integral Component Of Presynaptic Active Zone Membrane
Integral Component Of Postsynaptic Density Membrane
Molecular Function
Angiotensin Type I Receptor Activity
G Protein-coupled Receptor Activity
Angiotensin Type II Receptor Activity
Protein Binding
Bradykinin Receptor Binding
Protein Heterodimerization Activity
Type 1 Fibroblast Growth Factor Receptor Binding
Protein Binding
Ion Channel Binding
Cell Adhesion Molecule Binding
Cell-cell Adhesion Mediator Activity
Biological Process
Regulation Of Cell Growth
Kidney Development
Renin-angiotensin Regulation Of Aldosterone Production
Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin
Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin
Inflammatory Response
G Protein-coupled Receptor Signaling Pathway
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Rho Protein Signal Transduction
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cholesterol Esterification
Regulation Of Vasoconstriction
Calcium-mediated Signaling
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Phospholipase A2 Activity
Positive Regulation Of NAD(P)H Oxidase Activity
Low-density Lipoprotein Particle Remodeling
Regulation Of Renal Sodium Excretion
Angiotensin-activated Signaling Pathway
Regulation Of Cell Population Proliferation
Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway
Cell Chemotaxis
Phospholipase C-activating Angiotensin-activated Signaling Pathway
Blood Vessel Diameter Maintenance
Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Cytokine Production
Positive Regulation Of Protein Phosphorylation
Cellular Calcium Ion Homeostasis
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Positive Regulation Of Cytosolic Calcium Ion Concentration
Axon Guidance
Visual Learning
Positive Regulation Of Neuron Projection Development
Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Long-term Synaptic Potentiation
Positive Regulation Of ERK1 And ERK2 Cascade
Dendrite Self-avoidance
Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission
Positive Regulation Of Long-term Synaptic Potentiation
Regulation Of Receptor Localization To Synapse
Positive Regulation Of Cellular Protein Localization
Excitatory Synapse Assembly
Pathways
Peptide ligand-binding receptors
G alpha (q) signalling events
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
GABA receptor activation
Drugs
Valsartan
Olmesartan
Losartan
Candesartan cilexetil
Eprosartan
Telmisartan
Irbesartan
Forasartan
Saprisartan
Tasosartan
CYT006-AngQb
Azilsartan medoxomil
Fimasartan
Angiotensin II
Candesartan
Diseases
Renal tubular dysgenesis
GWAS
Birth weight (
31043758
)
Chin dimples (
27182965
)
Height (
31562340
)
Lead levels in blood (
25820613
)
Monobrow (
27182965
)
Type 2 diabetes (
31049640
)
Cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) with severe ocular complications (
28100913
)
Tourette syndrome (
30818990
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
76 interacting genes:
ABI3
ADD3
AGT
AGTRAP
AP2M1
ARFGAP1
ARHGDIG
ARRB1
ARRB2
ATP13A1
ATP1B1
BAALC
BASP1
BDKRB2
BNIP3
BRD8
CBR1
CCDC25
CD37
CERS6
CUEDC2
DBNDD2
DNAJC14
DNAJC8
EGFR
FAM13B
FBXW11
FNBP1
GHITM
GNA12
GOT1
GPAA1
GPRASP1
GRK2
GRK3
GRK5
HDGFL2
HHATL
HRAS
JAK1
JAK2
JKAMP
KIAA0930
LCNL1
LLGL1
LZTS1
NACAD
NDRG2
NOS3
NPTN
NUP88
OAZ1
PCMT1
PDE6H
PLCG1
PLCH2
PNMA1
PPP1R3F
PSMD10
PTGFR
RAB5A
RAF1
RBSN
RTN3
SAE1
SCG5
SELENOF
SERINC3
SLC16A1
SPG21
THOP1
TMEM161A
TMEM80
UBR4
UGT8
YWHAQ
3 interacting genes:
AGTR1
SURF2
UBC
Entrez ID
185
27020
HPRD ID
00107
18033
Ensembl ID
ENSG00000144891
ENSG00000156642
Uniprot IDs
A0A0A0MSE3
D3DNG8
P30556
Q53YY0
Q6NUP5
Q9Y639
PDB IDs
1ZV0
4YAY
4ZUD
6DO1
6OS0
6OS1
6OS2
6A69
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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