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AGTR1 and ATP1B1
Data Source:
BioGRID
(affinity chromatography technology, two hybrid)
AGTR1
ATP1B1
Description
angiotensin II receptor type 1
ATPase Na+/K+ transporting subunit beta 1
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Integral Component Of Membrane
Plasma Membrane
Sodium:potassium-exchanging ATPase Complex
Caveola
Intercalated Disc
Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Lateral Plasma Membrane
T-tubule
Organelle Membrane
Sperm Flagellum
Sarcolemma
Extracellular Exosome
Extracellular Vesicle
Molecular Function
Angiotensin Type I Receptor Activity
G Protein-coupled Receptor Activity
Angiotensin Type II Receptor Activity
Protein Binding
Bradykinin Receptor Binding
Protein Heterodimerization Activity
ATPase Activator Activity
Protein Binding
Protein C-terminus Binding
Protein Kinase Binding
MHC Class II Protein Complex Binding
Protein-macromolecule Adaptor Activity
Protein Heterodimerization Activity
ATPase Binding
Biological Process
Regulation Of Cell Growth
Kidney Development
Renin-angiotensin Regulation Of Aldosterone Production
Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin
Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin
Inflammatory Response
G Protein-coupled Receptor Signaling Pathway
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Rho Protein Signal Transduction
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cholesterol Esterification
Regulation Of Vasoconstriction
Calcium-mediated Signaling
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Phospholipase A2 Activity
Positive Regulation Of NAD(P)H Oxidase Activity
Low-density Lipoprotein Particle Remodeling
Regulation Of Renal Sodium Excretion
Angiotensin-activated Signaling Pathway
Regulation Of Cell Population Proliferation
Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway
Cell Chemotaxis
Phospholipase C-activating Angiotensin-activated Signaling Pathway
Blood Vessel Diameter Maintenance
Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Response To Hypoxia
Cellular Calcium Ion Homeostasis
Cellular Sodium Ion Homeostasis
Cell Adhesion
Establishment Or Maintenance Of Transmembrane Electrochemical Gradient
Regulation Of Gene Expression
Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling
Cellular Potassium Ion Homeostasis
Positive Regulation Of ATPase Activity
Ion Transmembrane Transport
Sodium Ion Transmembrane Transport
Sodium Ion Export Across Plasma Membrane
Protein Transport Into Plasma Membrane Raft
ATP Metabolic Process
Protein Stabilization
Leukocyte Migration
Relaxation Of Cardiac Muscle
Cardiac Muscle Contraction
Protein Localization To Plasma Membrane
Membrane Repolarization
Membrane Repolarization During Cardiac Muscle Cell Action Potential
Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Cation Transmembrane Transport
Positive Regulation Of Potassium Ion Transmembrane Transporter Activity
Positive Regulation Of Sodium Ion Export Across Plasma Membrane
Positive Regulation Of Calcium:sodium Antiporter Activity
Positive Regulation Of Potassium Ion Import Across Plasma Membrane
Positive Regulation Of Sodium:potassium-exchanging ATPase Activity
Regulation Of Cardiac Conduction
Potassium Ion Import Across Plasma Membrane
Pathways
Peptide ligand-binding receptors
G alpha (q) signalling events
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Basigin interactions
Ion homeostasis
Ion transport by P-type ATPases
Potential therapeutics for SARS
Drugs
Valsartan
Olmesartan
Losartan
Candesartan cilexetil
Eprosartan
Telmisartan
Irbesartan
Forasartan
Saprisartan
Tasosartan
CYT006-AngQb
Azilsartan medoxomil
Fimasartan
Angiotensin II
Candesartan
Diseases
Renal tubular dysgenesis
GWAS
Birth weight (
31043758
)
Chin dimples (
27182965
)
Height (
31562340
)
Lead levels in blood (
25820613
)
Monobrow (
27182965
)
Type 2 diabetes (
31049640
)
Coronary artery disease (
29212778
33020668
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Electrocardiographic traits (
32602732
25055868
)
Fuchs's corneal dystrophy (
28358029
)
Mitochondrial DNA levels (
25240745
)
QT interval (
23166209
29213071
24952745
19305409
29874175
)
Rosacea symptom severity (
29771307
)
Interacting Genes
76 interacting genes:
ABI3
ADD3
AGT
AGTRAP
AP2M1
ARFGAP1
ARHGDIG
ARRB1
ARRB2
ATP13A1
ATP1B1
BAALC
BASP1
BDKRB2
BNIP3
BRD8
CBR1
CCDC25
CD37
CERS6
CUEDC2
DBNDD2
DNAJC14
DNAJC8
EGFR
FAM13B
FBXW11
FNBP1
GHITM
GNA12
GOT1
GPAA1
GPRASP1
GRK2
GRK3
GRK5
HDGFL2
HHATL
HRAS
JAK1
JAK2
JKAMP
KIAA0930
LCNL1
LLGL1
LZTS1
NACAD
NDRG2
NOS3
NPTN
NUP88
OAZ1
PCMT1
PDE6H
PLCG1
PLCH2
PNMA1
PPP1R3F
PSMD10
PTGFR
RAB5A
RAF1
RBSN
RTN3
SAE1
SCG5
SELENOF
SERINC3
SLC16A1
SPG21
THOP1
TMEM161A
TMEM80
UBR4
UGT8
YWHAQ
21 interacting genes:
AGTR1
BACE1
BARD1
BRCA1
CRIP2
DDAH2
EGFR
EZH2
FXYD1
FXYD7
GCH1
HTR2B
KMT2B
LRIF1
NDRG2
PAXIP1
PSME1
TRIM14
TRMT2A
TSC22D2
USP4
Entrez ID
185
481
HPRD ID
00107
01663
Ensembl ID
ENSG00000144891
ENSG00000143153
Uniprot IDs
A0A0A0MSE3
D3DNG8
P30556
Q53YY0
Q6NUP5
A3KLL5
P05026
PDB IDs
1ZV0
4YAY
4ZUD
6DO1
6OS0
6OS1
6OS2
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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