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AGTR1 and FBXW11
Data Source:
BioGRID
(two hybrid)
AGTR1
FBXW11
Description
angiotensin II receptor type 1
F-box and WD repeat domain containing 11
Image
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Integral Component Of Membrane
Ubiquitin Ligase Complex
Kinetochore
Nucleus
Nuclear Envelope
Centrosome
Cytosol
Microtubule Associated Complex
Cytoplasmic Microtubule
SCF Ubiquitin Ligase Complex
Neuron Projection
Neuronal Cell Body
Axon Cytoplasm
Molecular Function
Angiotensin Type I Receptor Activity
G Protein-coupled Receptor Activity
Angiotensin Type II Receptor Activity
Protein Binding
Bradykinin Receptor Binding
Protein Heterodimerization Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Protein Dimerization Activity
Microtubule Plus-end Binding
Dynein Complex Binding
Biological Process
Regulation Of Cell Growth
Kidney Development
Renin-angiotensin Regulation Of Aldosterone Production
Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin
Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin
Inflammatory Response
G Protein-coupled Receptor Signaling Pathway
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Rho Protein Signal Transduction
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cholesterol Esterification
Regulation Of Vasoconstriction
Calcium-mediated Signaling
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Phospholipase A2 Activity
Positive Regulation Of NAD(P)H Oxidase Activity
Low-density Lipoprotein Particle Remodeling
Regulation Of Renal Sodium Excretion
Angiotensin-activated Signaling Pathway
Regulation Of Cell Population Proliferation
Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway
Cell Chemotaxis
Phospholipase C-activating Angiotensin-activated Signaling Pathway
Blood Vessel Diameter Maintenance
Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Positive Regulation Of Reactive Oxygen Species Metabolic Process
G2/M Transition Of Mitotic Cell Cycle
Establishment Of Mitotic Spindle Orientation
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Protein Dephosphorylation
Nuclear Migration
Germ Cell Development
Retrograde Axonal Transport
Viral Process
Wnt Signaling Pathway
Protein Ubiquitination
Microtubule Organizing Center Organization
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Destabilization
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Circadian Rhythm
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Positive Regulation Of Proteolysis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Vesicle Transport Along Microtubule
Rhythmic Process
Brain Morphogenesis
T Cell Receptor Signaling Pathway
Stress-activated MAPK Cascade
Interleukin-1-mediated Signaling Pathway
Regulation Of Microtubule Motor Activity
Pathways
Peptide ligand-binding receptors
G alpha (q) signalling events
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Activation of NF-kappaB in B cells
Downstream TCR signaling
Regulation of PLK1 Activity at G2/M Transition
FCERI mediated NF-kB activation
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Valsartan
Olmesartan
Losartan
Candesartan cilexetil
Eprosartan
Telmisartan
Irbesartan
Forasartan
Saprisartan
Tasosartan
CYT006-AngQb
Azilsartan medoxomil
Fimasartan
Angiotensin II
Candesartan
Diseases
Renal tubular dysgenesis
GWAS
Birth weight (
31043758
)
Chin dimples (
27182965
)
Height (
31562340
)
Lead levels in blood (
25820613
)
Monobrow (
27182965
)
Type 2 diabetes (
31049640
)
Height (
28552196
20881960
25282103
25429064
23563607
31562340
)
Waist circumference adjusted for BMI (adjusted for smoking behaviour) (
28443625
)
Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) (
28448500
)
Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) (
28443625
)
Waist circumference adjusted for BMI in active individuals (
28448500
)
Waist circumference adjusted for BMI in non-smokers (
28443625
)
Waist circumference adjusted for body mass index (
25673412
28448500
)
Interacting Genes
76 interacting genes:
ABI3
ADD3
AGT
AGTRAP
AP2M1
ARFGAP1
ARHGDIG
ARRB1
ARRB2
ATP13A1
ATP1B1
BAALC
BASP1
BDKRB2
BNIP3
BRD8
CBR1
CCDC25
CD37
CERS6
CUEDC2
DBNDD2
DNAJC14
DNAJC8
EGFR
FAM13B
FBXW11
FNBP1
GHITM
GNA12
GOT1
GPAA1
GPRASP1
GRK2
GRK3
GRK5
HDGFL2
HHATL
HRAS
JAK1
JAK2
JKAMP
KIAA0930
LCNL1
LLGL1
LZTS1
NACAD
NDRG2
NOS3
NPTN
NUP88
OAZ1
PCMT1
PDE6H
PLCG1
PLCH2
PNMA1
PPP1R3F
PSMD10
PTGFR
RAB5A
RAF1
RBSN
RTN3
SAE1
SCG5
SELENOF
SERINC3
SLC16A1
SPG21
THOP1
TMEM161A
TMEM80
UBR4
UGT8
YWHAQ
25 interacting genes:
AGTR1
BHLHE41
BTRC
CDC25A
CSNK1E
CUL1
DAPK1
GLI2
GSK3B
IFNAR1
KDR
MCL1
NFKB1
NFKBIA
PPP1CC
PPP2R1B
PPP2R5E
PRKACA
PRLR
PTEN
TBC1D4
TRIM21
UBE2D3
WEE1
ZNF281
Entrez ID
185
23291
HPRD ID
00107
07294
Ensembl ID
ENSG00000144891
ENSG00000072803
Uniprot IDs
A0A0A0MSE3
D3DNG8
P30556
Q53YY0
Q6NUP5
B4DH70
Q9UKB1
PDB IDs
1ZV0
4YAY
4ZUD
6DO1
6OS0
6OS1
6OS2
6WNX
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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