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PDGFA and COL3A1
Data Source:
BioGRID
(pull down)
PDGFA
COL3A1
Description
platelet derived growth factor subunit A
collagen type III alpha 1 chain
Image
GO Annotations
Cellular Component
Golgi Membrane
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Golgi Lumen
Microvillus
Cell Surface
Platelet Alpha Granule Lumen
Extracellular Region
Collagen Type III Trimer
Extracellular Space
Endoplasmic Reticulum Lumen
Extracellular Matrix
Collagen-containing Extracellular Matrix
Molecular Function
Platelet-derived Growth Factor Receptor Binding
Protein Binding
Collagen Binding
Growth Factor Activity
Protein Homodimerization Activity
Protein Heterodimerization Activity
Platelet-derived Growth Factor Binding
Growth Factor Receptor Binding
Protease Binding
Integrin Binding
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Metal Ion Binding
Platelet-derived Growth Factor Binding
Biological Process
MAPK Cascade
Angiogenesis
Cell Activation
Hair Follicle Development
Positive Regulation Of Mesenchymal Cell Proliferation
Platelet Degranulation
Cell-cell Signaling
Positive Regulation Of Cell Population Proliferation
Response To Wounding
Animal Organ Morphogenesis
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Negative Regulation Of Platelet Activation
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Regulation Of Smooth Muscle Cell Migration
Cell Projection Assembly
Actin Cytoskeleton Organization
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Protein Autophosphorylation
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Wound Healing
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Skin Development
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Fibroblast Proliferation
Lung Alveolus Development
Regulation Of Peptidyl-tyrosine Phosphorylation
Negative Chemotaxis
Positive Regulation Of Cell Division
Positive Regulation Of Protein Kinase B Signaling
Regulation Of Branching Involved In Salivary Gland Morphogenesis By Epithelial-mesenchymal Signaling
Positive Regulation Of ERK1 And ERK2 Cascade
Regulation Of Glomerular Mesangial Cell Proliferation
Embryonic Lung Development
Regulation Of DNA Biosynthetic Process
Skeletal System Development
Cell-matrix Adhesion
Transforming Growth Factor Beta Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Heart Development
Response To Radiation
Response To Mechanical Stimulus
Peptide Cross-linking
Cerebral Cortex Development
Platelet Activation
Extracellular Matrix Organization
Collagen Fibril Organization
Response To Cytokine
Positive Regulation Of Rho Protein Signal Transduction
Wound Healing
Skin Development
Regulation Of Immune Response
Negative Regulation Of Immune Response
Supramolecular Fiber Organization
Negative Regulation Of Neuron Migration
Pathways
Non-integrin membrane-ECM interactions
Collagen degradation
Collagen degradation
Extracellular matrix organization
Collagen biosynthesis and modifying enzymes
Signaling by PDGF
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
ECM proteoglycans
Scavenging by Class A Receptors
NCAM1 interactions
MET activates PTK2 signaling
Collagen chain trimerization
Drugs
Collagenase clostridium histolyticum
Diseases
Malignant pleural mesothelioma
Glioma
Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS
Male-pattern baldness (
28196072
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Carotid intima media thickness x smoking interaction (
32117412
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Parkinson disease and lewy body pathology (
25663231
)
Platelet distribution width (
32888494
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
17 interacting genes:
A2M
ASPH
COL1A1
COL1A2
COL2A1
COL3A1
COL4A1
COL5A1
COL6A1
DUSP3
FURIN
HSPG2
MBD3
MDFI
PDAP1
PDGFRA
SPARC
14 interacting genes:
AP2B1
CAPN1
DDR1
DDR2
FGF7
HTRA1
MAG
MYOC
PCOLCE
PDGFA
PDGFB
SPARC
THBS1
VWF
Entrez ID
5154
1281
HPRD ID
01424
00365
Ensembl ID
ENSG00000197461
ENSG00000168542
Uniprot IDs
P04085
P02461
PDB IDs
3MJK
2V53
3DMW
4AE2
4AEJ
4AK3
4GYX
6FZV
6FZW
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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