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PDGFA and COL5A1
Data Source:
BioGRID
(pull down)
PDGFA
COL5A1
Description
platelet derived growth factor subunit A
collagen type V alpha 1 chain
Image
GO Annotations
Cellular Component
Golgi Membrane
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Golgi Lumen
Microvillus
Cell Surface
Platelet Alpha Granule Lumen
Extracellular Region
Collagen Type V Trimer
Basement Membrane
Extracellular Space
Endoplasmic Reticulum Lumen
Extracellular Matrix
Collagen-containing Extracellular Matrix
Molecular Function
Platelet-derived Growth Factor Receptor Binding
Protein Binding
Collagen Binding
Growth Factor Activity
Protein Homodimerization Activity
Protein Heterodimerization Activity
Platelet-derived Growth Factor Binding
Growth Factor Receptor Binding
Integrin Binding
Extracellular Matrix Structural Constituent
Protein Binding
Heparin Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Proteoglycan Binding
Metal Ion Binding
Platelet-derived Growth Factor Binding
Biological Process
MAPK Cascade
Angiogenesis
Cell Activation
Hair Follicle Development
Positive Regulation Of Mesenchymal Cell Proliferation
Platelet Degranulation
Cell-cell Signaling
Positive Regulation Of Cell Population Proliferation
Response To Wounding
Animal Organ Morphogenesis
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Negative Regulation Of Platelet Activation
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Regulation Of Smooth Muscle Cell Migration
Cell Projection Assembly
Actin Cytoskeleton Organization
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Protein Autophosphorylation
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Wound Healing
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Skin Development
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Fibroblast Proliferation
Lung Alveolus Development
Regulation Of Peptidyl-tyrosine Phosphorylation
Negative Chemotaxis
Positive Regulation Of Cell Division
Positive Regulation Of Protein Kinase B Signaling
Regulation Of Branching Involved In Salivary Gland Morphogenesis By Epithelial-mesenchymal Signaling
Positive Regulation Of ERK1 And ERK2 Cascade
Regulation Of Glomerular Mesangial Cell Proliferation
Embryonic Lung Development
Regulation Of DNA Biosynthetic Process
Blood Vessel Development
Heart Morphogenesis
Cell Adhesion
Cell Migration
Extracellular Matrix Organization
Collagen Fibril Organization
Collagen Biosynthetic Process
Wound Healing, Spreading Of Epidermal Cells
Tendon Development
Skin Development
Integrin Biosynthetic Process
Eye Morphogenesis
Regulation Of Cellular Component Organization
Supramolecular Fiber Organization
Negative Regulation Of Endodermal Cell Differentiation
Pathways
Non-integrin membrane-ECM interactions
Collagen degradation
Extracellular matrix organization
Collagen biosynthesis and modifying enzymes
Signaling by PDGF
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
NCAM1 interactions
MET activates PTK2 signaling
Collagen chain trimerization
Drugs
Diseases
Malignant pleural mesothelioma
Glioma
Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS
Male-pattern baldness (
28196072
)
Blood pressure (
24954895
)
Central corneal thickness (
32528159
28171582
22814818
31798171
23493294
29760442
30894546
20719862
)
Corneal structure (
23291589
)
Crohn's disease (need for surgery) (
23665963
)
Intraocular pressure (
29617998
)
Longevity (
20834067
)
Metabolite levels (
23823483
)
Phosphatidylcholine levels (
31551469
)
Refractive error (
32231278
)
Interacting Genes
17 interacting genes:
A2M
ASPH
COL1A1
COL1A2
COL2A1
COL3A1
COL4A1
COL5A1
COL6A1
DUSP3
FURIN
HSPG2
MBD3
MDFI
PDAP1
PDGFRA
SPARC
10 interacting genes:
BMP1
COL5A3
DCN
LGALS3BP
MAG
PDGFA
PDGFB
SDC3
SPARC
THBS1
Entrez ID
5154
1289
HPRD ID
01424
00368
Ensembl ID
ENSG00000197461
ENSG00000130635
Uniprot IDs
P04085
A0A024R8E5
B2ZZ86
P20908
Q59EE7
PDB IDs
3MJK
1A89
1A9A
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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