KRT28 and KRT1

Data Source:
BioGRID (two hybrid)

		KRT28	KRT1
Description		keratin 28	keratin 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Extracellular Exosome	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytosol Cytoskeleton Membrane Keratin Filament Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	Molecular_function Structural Molecule Activity Protein Binding	Protein Binding Carbohydrate Binding Structural Constituent Of Skin Epidermis Signaling Receptor Activity Protein Heterodimerization Activity
	Biological Process	Biological_process Keratinization Cornification	Complement Activation, Lectin Pathway Retina Homeostasis Response To Oxidative Stress Peptide Cross-linking Keratinization Fibrinolysis Neutrophil Degranulation Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Protein Heterotetramerization Establishment Of Skin Barrier Cornification
Pathways		Keratinization Formation of the cornified envelope	Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs			Zinc Copper Zinc acetate
Diseases			Epidermolytic palmoplantar keratoderma (EPPK) Ichthyosis hystrix, Curth-Macklin type Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE) Striate palmoplantar keratoderma
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Glucose homeostasis traits ( 25524916)
Interacting Genes		19 interacting genes: ABI3 CCDC196 DEUP1 KRT1 KRT3 KRT4 KRT5 KRT6A KRT6B KRT71 KRT79 KRT8 KRT80 KRT81 KRT86 NUP58 UCHL5 USHBP1 WASHC1	51 interacting genes: AMOTL2 CALB2 CSTA DSP EVPL F12 FANCA FANCC FFAR2 GOLGA2 GOLGA6L9 HAUS1 HMG20A HOOK2 IVL KNG1 KRT13 KRT14 KRT15 KRT16 KRT19 KRT24 KRT25 KRT26 KRT27 KRT28 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT5 LINC00839 LORICRIN MBL2 NINL NUP62 PI3 PRKCE RINT1 SGTB TFIP11 TLCD4 TRIM54 U2AF1 U2AF1L5 UBE3A YWHAQ
Entrez ID		162605	3848
HPRD ID		17245	00763
Ensembl ID		ENSG00000173908	ENSG00000167768
Uniprot IDs		Q7Z3Y7	P04264
PDB IDs			4ZRY 6E2J 6UUI
Enriched GO Terms of Interacting Partners?
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