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USP54 and CDC23
Data Source:
BioGRID
(two hybrid)
USP54
CDC23
Description
ubiquitin specific peptidase 54
cell division cycle 23
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Anaphase-promoting Complex
Cytoplasm
Cytosol
Molecular Function
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Biological Process
Protein Deubiquitination
Protein Phosphopantetheinylation
Mitotic Cell Cycle
Ubiquitin-dependent Protein Catabolic Process
Mitotic Metaphase Plate Congression
Metaphase/anaphase Transition Of Mitotic Cell Cycle
Regulation Of Exit From Mitosis
Protein Ubiquitination
Regulation Of Mitotic Metaphase/anaphase Transition
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Cell Division
Protein K11-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism (
32438682
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Autism spectrum disorder or schizophrenia (
28540026
)
Resting heart rate (
27798624
)
Interacting Genes
88 interacting genes:
ANKRD11
ANKS1A
ARMC7
ATN1
ATXN1
ATXN1L
ATXN7L2
BFSP2
BHLHE40
CARD10
CCDC13
CCDC24
CCNK
CDC23
CHCHD2
CHERP
CHMP1B
CHMP2A
CHMP2B
CHMP4C
CSTF2
CYSRT1
DMRT3
DOK6
DTX2
EIF4E2
EPM2AIP1
EXOC8
FAM124B
FBXO17
FNDC3B
FOXI1
GCM2
HGS
HNF1B
HNRNPF
HOXC8
IGFN1
INSC
KCTD9
LMO3
LNX1
MED25
MID2
NUDT22
NXT2
OIP5
OTX1
PCSK5
PHF1
PLA2G6
PLAC8
PLEKHN1
POLR1C
PRDM6
PRKAB2
PRR35
QRICH1
RACK1
RAMAC
RBPMS2
RHOBTB3
RNF208
SEC24A
SHARPIN
SHC3
SMARCD1
SMYD1
SNRPB
SS18L1
STK16
TBX6
TCEA2
TEKT5
TENT5B
TFAP2D
TLE5
TNS2
TOLLIP
TSEN15
TSSK3
TTC19
UBC
USP2
VENTX
ZCCHC14
ZNF148
ZNF76
81 interacting genes:
ANAPC10
ANAPC13
ANKRD11
APOL1
ATRIP
BCAS3
BEGAIN
BHLHB9
BYSL
C21orf91
CBY2
CCDC125
CCDC24
CCDC33
CDC16
CDT1
CEP44
CERCAM
COIL
CRACR2A
CRTC2
CTBP1
CYB5R2
DCLK1
DEPDC1B
DISC1
DLX6-AS1
EIF5A2
FAM9B
FBXO5
FOXN1
GORASP2
GTPBP8
HEMK1
IHO1
INCA1
INO80E
INPP5J
KCTD6
KDM1A
KRT36
LHX3
LZTS1
LZTS2
MAGED1
MAPK3
NAB2
NRBF2
NUP54
OPTN
PFKFB4
PIH1D2
PNMA5
POU6F2
PROSER3
PRPF31
PRR22
RAC1
RAD54B
RBM15B
RBP3
RBPMS
RSL24D1
RUNX1T1
SIAH1
SLC52A2
SMARCB1
SMUG1
SORBS3
SOX5
SPAG8
SSX2IP
STX2
SUV39H1
TEPSIN
TNIP1
TRIM27
TSC22D4
UBE2S
USP54
ZMAT1
Entrez ID
159195
8697
HPRD ID
15641
07221
Ensembl ID
ENSG00000166348
ENSG00000094880
Uniprot IDs
B7Z7X1
Q70EL1
Q9UJX2
PDB IDs
4UI9
5A31
5G04
5G05
5KHR
5KHU
5L9T
5L9U
5LCW
6Q6G
6Q6H
6TLJ
6TM5
Enriched GO Terms of Interacting Partners
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