ESCO2 and SMC3

Data Source:
BioGRID (enzymatic study)

		ESCO2	SMC3
Description		establishment of sister chromatid cohesion N-acetyltransferase 2	structural maintenance of chromosomes 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin XY Body Nucleoplasm Chromosome Pericentric Heterochromatin Golgi Apparatus Chromocenter Cell Junction Site Of Double-strand Break	Chromosome, Centromeric Region Chromatin Lateral Element Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Meiotic Cohesin Complex Nuclear Meiotic Cohesin Complex Mitotic Spindle Pole
	Molecular Function	Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding Acetyltransferase Activity Metal Ion Binding	Chromatin Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Protein Heterodimerization Activity Beta-tubulin Binding Dynein Complex Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Regulation Of DNA Replication Double-strand Break Repair Sister Chromatid Cohesion Post-translational Protein Acetylation Protein Localization To Chromatin	Mitotic Cell Cycle Regulation Of DNA Replication DNA Repair Sister Chromatid Cohesion Stem Cell Population Maintenance Cell Division Meiotic Cell Cycle Mitotic Spindle Assembly
Pathways		Establishment of Sister Chromatid Cohesion	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases		ESCO2-related disorders, including: Roberts syndrome; SC phocomelia syndrome	Cornelia de Lange syndrome (CdLS)
GWAS			Acute respiratory distress syndrome in sepsis ( 31982041) Lumbar spine bone mineral density (integral) ( 27476799) Metabolite levels ( 23823483)
Interacting Genes		12 interacting genes: FXR1 GOLGA2 MCM2 MCM4 MCM5 MCM6 MCM7 MMS22L PCNA PICK1 RABEP1 SMC3	18 interacting genes: APC CEP63 DISC1 ESCO2 ESR1 FEZ1 FEZ2 KIFAP3 MTNR1B MXD1 MXD3 MXD4 MXI1 RPGR SMC1A SMC1B SUMO2 TRAF3IP1
Entrez ID		157570	9126
HPRD ID		18564	05829
Ensembl ID		ENSG00000171320	ENSG00000108055
Uniprot IDs		Q56NI9	Q9UQE7
PDB IDs			6WG3 6WG4 6WG6 6WGE
Enriched GO Terms of Interacting Partners?
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