ESCO2 and MCM4

Data Source:
BioGRID (two hybrid)

		ESCO2	MCM4
Description		establishment of sister chromatid cohesion N-acetyltransferase 2	minichromosome maintenance complex component 4
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin XY Body Nucleoplasm Chromosome Pericentric Heterochromatin Golgi Apparatus Chromocenter Cell Junction Site Of Double-strand Break	Chromosome, Telomeric Region Nucleus Nucleoplasm Membrane MCM Complex CMG Complex
	Molecular Function	Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding Acetyltransferase Activity Metal Ion Binding	DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Regulation Of DNA Replication Double-strand Break Repair Sister Chromatid Cohesion Post-translational Protein Acetylation Protein Localization To Chromatin	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Strand Elongation Involved In DNA Replication Mitotic DNA Replication Initiation
Pathways		Establishment of Sister Chromatid Cohesion	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases		ESCO2-related disorders, including: Roberts syndrome; SC phocomelia syndrome
GWAS			Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Eosinophil percentage of white cells ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252) Reticulocyte count ( 32888494)
Interacting Genes		12 interacting genes: FXR1 GOLGA2 MCM2 MCM4 MCM5 MCM6 MCM7 MMS22L PCNA PICK1 RABEP1 SMC3	27 interacting genes: CCNA1 CDC5L CDC7 CDK1 CDK2 CDT1 DBF4 EP300 ESCO2 LIG4 MCM2 MCM3 MCM6 MCM7 MCM8 MCMBP ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 RPA1 SSRP1 SUMO2 SUPT16H TLX2
Entrez ID		157570	4173
HPRD ID		18564	09094
Ensembl ID		ENSG00000171320	ENSG00000104738
Uniprot IDs		Q56NI9	B3KMX0 B4DLA6 P33991
PDB IDs			6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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