ESCO2 and MMS22L

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ESCO2	MMS22L
Description		establishment of sister chromatid cohesion N-acetyltransferase 2	MMS22 like, DNA repair protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin XY Body Nucleoplasm Chromosome Pericentric Heterochromatin Golgi Apparatus Chromocenter Cell Junction Site Of Double-strand Break	Nucleoplasm Cytosol FACT Complex MCM Complex Nuclear Replication Fork
	Molecular Function	Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding Acetyltransferase Activity Metal Ion Binding	Protein Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Regulation Of DNA Replication Double-strand Break Repair Sister Chromatid Cohesion Post-translational Protein Acetylation Protein Localization To Chromatin	Double-strand Break Repair Via Homologous Recombination Replication Fork Processing
Pathways		Establishment of Sister Chromatid Cohesion
Drugs
Diseases		ESCO2-related disorders, including: Roberts syndrome; SC phocomelia syndrome
GWAS			Adult body size ( 32376654) Automobile speeding propensity ( 30643258) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Chronotype ( 30696823) Gut microbiota (bacterial taxa) ( 27694959) Hand grip strength ( 29691431) Morning person ( 30696823) Multiple sclerosis (OCB status) ( 23785401) Number of sexual partners ( 30643258) Photic sneeze reflex ( 27182965) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
Interacting Genes		12 interacting genes: FXR1 GOLGA2 MCM2 MCM4 MCM5 MCM6 MCM7 MMS22L PCNA PICK1 RABEP1 SMC3	4 interacting genes: ESCO2 FBXW7 RAD51 RPA1
Entrez ID		157570	253714
HPRD ID		18564	12865
Ensembl ID		ENSG00000171320	ENSG00000146263
Uniprot IDs		Q56NI9	Q6ZRQ5
PDB IDs
Enriched GO Terms of Interacting Partners?
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