FGD5 and JMJD6

Data Source:
BioGRID (two hybrid)

		FGD5	JMJD6
Description		FYVE, RhoGEF and PH domain containing 5	jumonji domain containing 6, arginine demethylase and lysine hydroxylase
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GO Annotations	Cellular Component	Ruffle Cytoplasm Early Endosome Endoplasmic Reticulum Golgi Apparatus Cytoskeleton Plasma Membrane Lamellipodium Ruffle Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Ribonucleoprotein Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding Metal Ion Binding	RNA Binding Single-stranded RNA Binding Iron Ion Binding Protein Binding Demethylase Activity Histone Demethylase Activity Histone Demethylase Activity (H3-R2 Specific) Histone Demethylase Activity (H4-R3 Specific) Oxidative RNA Demethylase Activity Signaling Receptor Activity Identical Protein Binding Peptidyl-lysine 5-dioxygenase Activity P-TEFb Complex Binding Transcription Regulator Activator Activity
	Biological Process	Cytoskeleton Organization Regulation Of Cell Shape Actin Cytoskeleton Organization Regulation Of GTPase Activity Filopodium Assembly	Kidney Development Sprouting Angiogenesis MRNA Processing Protein Demethylation Cell Surface Receptor Signaling Pathway Heart Development RNA Splicing Protein Phosphopantetheinylation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Lung Development T Cell Differentiation In Thymus Oxidative RNA Demethylation Macrophage Activation Recognition Of Apoptotic Cell Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Erythrocyte Development Protein Homooligomerization Retina Development In Camera-type Eye Histone H3-R2 Demethylation Histone H4-R3 Demethylation
Pathways			HDMs demethylate histones
Drugs
Diseases
GWAS		Alcohol dependence ( 24166409) Coronary artery disease ( 32469254 29212778 28714974 33020668) Diastolic blood pressure ( 28135244 27841878 29403010 27618452 30487518) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hypertension ( 31217584 30487518) Mean arterial pressure ( 29403010 30487518) Offspring birth weight ( 31043758) Pulse pressure ( 30578418) Red blood cell count ( 32888494) Systolic blood pressure ( 27841878 29403010 27618452 30487518 30578418)	Neutrophil count ( 32888494) Retinal arteriolar caliber ( 23776548)
Interacting Genes		3 interacting genes: JMJD6 RAC1 SUV39H1	27 interacting genes: AEBP2 ANKEF1 C17orf97 CCNL1 CENPL CXCL14 DIP2A FGD5 FRMD6 GNA14 H2BC11 H3C1 H4C1 HMGXB4 LARP7 NAA50 NFIX NHP2 PRPF38A PSMC1 RSPO2 SLFN12 SLU7 STAC3 TAF1A U2AF1 ZNF451
Entrez ID		152273	23210
HPRD ID		13322	05371
Ensembl ID		ENSG00000154783	ENSG00000070495
Uniprot IDs		A0A2X0SFF2 B7ZM68 Q6ZNL6	Q6NYC1
PDB IDs		3MPX	3K2O 3LD8 3LDB 6BNH 6GDY 6MEV
Enriched GO Terms of Interacting Partners?
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