ADRA2A and GGA3

Data Source:
BioGRID (pull down)

		ADRA2A	GGA3
Description		adrenoceptor alpha 2A	golgi associated, gamma adaptin ear containing, ARF binding protein 3
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Receptor Complex Dopaminergic Synapse	Lysosome Golgi Apparatus Trans-Golgi Network Endosome Membrane Early Endosome Membrane Protein-containing Complex Recycling Endosome Membrane
	Molecular Function	G Protein-coupled Receptor Activity Alpha2-adrenergic Receptor Activity Protein Binding Protein Kinase Binding Alpha-1B Adrenergic Receptor Binding Alpha-2C Adrenergic Receptor Binding Thioesterase Binding Heterotrimeric G-protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Epinephrine Binding Norepinephrine Binding	Protein Binding Small GTPase Binding Ubiquitin Binding Protein-containing Complex Binding
	Biological Process	Positive Regulation Of Cytokine Production Regulation Of Smooth Muscle Contraction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Cell Population Proliferation Negative Regulation Of Norepinephrine Secretion Regulation Of Vasoconstriction Actin Cytoskeleton Organization Platelet Activation Positive Regulation Of Cell Migration Activation Of Protein Kinase Activity Activation Of Protein Kinase B Activity Negative Regulation Of Epinephrine Secretion Cellular Response To Hormone Stimulus Receptor Transactivation Glucose Homeostasis Fear Response Positive Regulation Of Potassium Ion Transport Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Intestinal Absorption Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Calcium Ion Transport Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Phospholipase C-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Wound Healing Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Synaptic Vesicle Exocytosis	Protein Targeting To Lysosome Intracellular Protein Transport Regulation Of Protein Stability Protein Destabilization Endocytic Recycling Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Cellular Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Amyloid-beta Formation
Pathways		Adrenoceptors Adrenaline signalling through Alpha-2 adrenergic receptor Adrenaline,noradrenaline inhibits insulin secretion G alpha (i) signalling events G alpha (z) signalling events Surfactant metabolism	TBC/RABGAPs MET receptor recycling Amyloid fiber formation
Drugs		Amphetamine Tramadol Bethanidine Ziprasidone Cabergoline Ropinirole Dihydroergotamine Amitriptyline Clozapine Norepinephrine Mirtazapine Phenylpropanolamine Loxapine Pramipexole Prochlorperazine Dipivefrin Prazosin Chlorpromazine Brimonidine Haloperidol Nortriptyline Amoxapine Amoxapine Lamotrigine Clonidine Lisuride Guanabenz Dexmedetomidine Trazodone Epinephrine Phentolamine Ergotamine Tizanidine Apomorphine Paroxetine Trimipramine Epinastine Tolazoline Fenoldopam Pseudoephedrine Benzphetamine Phenoxybenzamine Maprotiline Oxymetazoline Apraclonidine Methyldopa Guanfacine Ergoloid mesylate Promethazine Carvedilol Nefazodone Desipramine Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra sinica root Mephentermine Yohimbine Methotrimeprazine 4-Methoxyamphetamine Dextroamphetamine Metamfetamine Periciazine Zuclopenthixol Celiprolol Dronedarone Lofexidine Epicept NP-1 Mianserin Pizotifen Asenapine Ocaperidone Droxidopa Flupirtine Esmirtazapine Xylometazoline Levonordefrin Naphazoline Lurasidone Dosulepin Etoperidone Lorpiprazole Cirazoline Moxisylyte Aranidipine Moxonidine Pirlindole Pipamperone Setiptiline Racepinephrine Dihydroergocornine DL-Methylephedrine DL-Methylephedrine Xylazine Indigotindisulfonic acid Rilmenidine Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Fasting blood glucose ( 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fish- and plant-related diet ( 32066663) Homeostasis model assessment of beta-cell function ( 20081858) Longitudinal alcohol consumption ( 26081443) Platelet aggregation ( 20526338 29185836)
Interacting Genes		14 interacting genes: ADRB1 EIF2B1 GGA3 GNAI1 GNAI2 GNAO1 GNB1 GNG2 GRK2 PPP1R9B PRKCD SNTA1 UCHL1 YWHAZ	38 interacting genes: ADRA2A ADRA2B AFTPH AP1S2 ARAP3 ARF1 ARF3 CDKN2A CLINT1 CLTC CYTH2 DAZAP2 EGFR GGA1 GGA2 IGF2R LITAF LRP10 M6PR P4HA3 PACS1 PLEKHB2 RABEP1 RNF11 RNF214 RPS27A STAB1 SYNRG TBC1D3 TOLLIP TRAPPC6A TRIM23 TSG101 UBC UPRT VPS11 VPS18 ZNF497
Entrez ID		150	23163
HPRD ID		00078	10443
Ensembl ID		ENSG00000150594	ENSG00000125447
Uniprot IDs		P08913	A8K6M0 B7Z456 Q9NZ52
PDB IDs		1HLL 1HO9 1HOD 1HOF 6K42 6KUX 6KUY	1JPL 1JUQ 1LF8 1P4U 1WR6 1YD8
Enriched GO Terms of Interacting Partners?
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