ADRA2A and ADRB1

Data Source:
HPRD (in vivo)

		ADRA2A	ADRB1
Description		adrenoceptor alpha 2A	adrenoceptor beta 1
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Receptor Complex Dopaminergic Synapse	Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Schaffer Collateral - CA1 Synapse
	Molecular Function	G Protein-coupled Receptor Activity Alpha2-adrenergic Receptor Activity Protein Binding Protein Kinase Binding Alpha-1B Adrenergic Receptor Binding Alpha-2C Adrenergic Receptor Binding Thioesterase Binding Heterotrimeric G-protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Epinephrine Binding Norepinephrine Binding	G Protein-coupled Receptor Activity Beta-adrenergic Receptor Activity Beta1-adrenergic Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding PDZ Domain Binding Alpha-2A Adrenergic Receptor Binding Protein Heterodimerization Activity G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Positive Regulation Of Cytokine Production Regulation Of Smooth Muscle Contraction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Cell Population Proliferation Negative Regulation Of Norepinephrine Secretion Regulation Of Vasoconstriction Actin Cytoskeleton Organization Platelet Activation Positive Regulation Of Cell Migration Activation Of Protein Kinase Activity Activation Of Protein Kinase B Activity Negative Regulation Of Epinephrine Secretion Cellular Response To Hormone Stimulus Receptor Transactivation Glucose Homeostasis Fear Response Positive Regulation Of Potassium Ion Transport Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Intestinal Absorption Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Calcium Ion Transport Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Phospholipase C-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Wound Healing Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Synaptic Vesicle Exocytosis	Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Diet Induced Thermogenesis Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Response To Cold Heat Generation Negative Regulation Of Multicellular Organism Growth Fear Response Positive Regulation Of GTPase Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Brown Fat Cell Differentiation Regulation Of Postsynaptic Membrane Potential Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis
Pathways		Adrenoceptors Adrenaline signalling through Alpha-2 adrenergic receptor Adrenaline,noradrenaline inhibits insulin secretion G alpha (i) signalling events G alpha (z) signalling events Surfactant metabolism	Adrenoceptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Amphetamine Tramadol Bethanidine Ziprasidone Cabergoline Ropinirole Dihydroergotamine Amitriptyline Clozapine Norepinephrine Mirtazapine Phenylpropanolamine Loxapine Pramipexole Prochlorperazine Dipivefrin Prazosin Chlorpromazine Brimonidine Haloperidol Nortriptyline Amoxapine Amoxapine Lamotrigine Clonidine Lisuride Guanabenz Dexmedetomidine Trazodone Epinephrine Phentolamine Ergotamine Tizanidine Apomorphine Paroxetine Trimipramine Epinastine Tolazoline Fenoldopam Pseudoephedrine Benzphetamine Phenoxybenzamine Maprotiline Oxymetazoline Apraclonidine Methyldopa Guanfacine Ergoloid mesylate Promethazine Carvedilol Nefazodone Desipramine Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra sinica root Mephentermine Yohimbine Methotrimeprazine 4-Methoxyamphetamine Dextroamphetamine Metamfetamine Periciazine Zuclopenthixol Celiprolol Dronedarone Lofexidine Epicept NP-1 Mianserin Pizotifen Asenapine Ocaperidone Droxidopa Flupirtine Esmirtazapine Xylometazoline Levonordefrin Naphazoline Lurasidone Dosulepin Etoperidone Lorpiprazole Cirazoline Moxisylyte Aranidipine Moxonidine Pirlindole Pipamperone Setiptiline Racepinephrine Dihydroergocornine DL-Methylephedrine DL-Methylephedrine Xylazine Indigotindisulfonic acid Rilmenidine Tiapride Dihydroergocristine Aripiprazole lauroxil	Spermine Amphetamine Esmolol Betaxolol Bethanidine Isoetharine Ranolazine Cabergoline Metoprolol Olanzapine Atenolol Norepinephrine Timolol Phenylpropanolamine Loxapine Sotalol Carteolol Nortriptyline Lamotrigine Propranolol Labetalol Bisoprolol Epinephrine Paroxetine Trimipramine Cryptenamine Dobutamine Pseudoephedrine Alprenolol Terbutaline Salmeterol Pindolol Formoterol Salbutamol Ergoloid mesylate Isoprenaline Arbutamine Amiodarone Carvedilol Desipramine Propafenone Acebutolol Nadolol Levobunolol Metipranolol Aripiprazole Fenoterol Pirbuterol Bevantolol Practolol Penbutolol Ephedra sinica root Ephedrine Mephentermine Clenbuterol Oxprenolol Putrescine Spermidine Celiprolol Dronedarone Nebivolol Asenapine Droxidopa Bufuralol 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL Bopindolol Bupranolol Befunolol Vortioxetine Arotinolol Levobetaxolol Racepinephrine Dihydroergocornine DL-Methylephedrine DL-Methylephedrine Dihydroergocristine Xamoterol
Diseases
GWAS		Fasting blood glucose ( 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fish- and plant-related diet ( 32066663) Homeostasis model assessment of beta-cell function ( 20081858) Longitudinal alcohol consumption ( 26081443) Platelet aggregation ( 20526338 29185836)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Birth weight ( 23202124 31043758 27680694) Blood pressure ( 21909110) Diastolic blood pressure ( 28135244 27841878 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Gaucher disease severity ( 22388998) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 29083408) LDL cholesterol levels ( 32203549) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Platelet distribution width ( 32888494) PR interval ( 32439900) Systolic blood pressure ( 27841878 28739976 27618447 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 32203549)
Interacting Genes		14 interacting genes: ADRB1 EIF2B1 GGA3 GNAI1 GNAI2 GNAO1 GNB1 GNG2 GRK2 PPP1R9B PRKCD SNTA1 UCHL1 YWHAZ	16 interacting genes: ADRA2A ARRB1 DLG1 DLG4 DLGAP2 GIPC1 GOPC GPRASP1 GPRASP2 GRB2 MAGI2 MAGI3 NOS1 SH3GL2 SH3GL3 SNTA1
Entrez ID		150	153
HPRD ID		00078	00181
Ensembl ID		ENSG00000150594	ENSG00000043591
Uniprot IDs		P08913	P08588
PDB IDs		1HLL 1HO9 1HOD 1HOF 6K42 6KUX 6KUY	2LSQ
Enriched GO Terms of Interacting Partners?
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