GGA3 and SYNRG

Data Source:
HPRD (two hybrid, in vivo)

		GGA3	SYNRG
Description		golgi associated, gamma adaptin ear containing, ARF binding protein 3	synergin gamma
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GO Annotations	Cellular Component	Lysosome Golgi Apparatus Trans-Golgi Network Endosome Membrane Early Endosome Membrane Protein-containing Complex Recycling Endosome Membrane	Cytoplasm Golgi Apparatus AP-1 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle
	Molecular Function	Protein Binding Small GTPase Binding Ubiquitin Binding Protein-containing Complex Binding	Protein Binding
	Biological Process	Protein Targeting To Lysosome Intracellular Protein Transport Regulation Of Protein Stability Protein Destabilization Endocytic Recycling Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Cellular Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Amyloid-beta Formation	Intracellular Protein Transport Endocytosis
Pathways		TBC/RABGAPs MET receptor recycling Amyloid fiber formation
Drugs
Diseases
GWAS			Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Ovarian cancer ( 23535730) Response to angiotensin II receptor blocker therapy ( 22566498)
Interacting Genes		38 interacting genes: ADRA2A ADRA2B AFTPH AP1S2 ARAP3 ARF1 ARF3 CDKN2A CLINT1 CLTC CYTH2 DAZAP2 EGFR GGA1 GGA2 IGF2R LITAF LRP10 M6PR P4HA3 PACS1 PLEKHB2 RABEP1 RNF11 RNF214 RPS27A STAB1 SYNRG TBC1D3 TOLLIP TRAPPC6A TRIM23 TSG101 UBC UPRT VPS11 VPS18 ZNF497	8 interacting genes: AP1G1 AP1G2 APPBP2 CCDC91 GGA1 GGA2 GGA3 SCAMP1
Entrez ID		23163	11276
HPRD ID		10443	06291
Ensembl ID		ENSG00000125447	ENSG00000275066
Uniprot IDs		A8K6M0 B7Z456 Q9NZ52	Q9UMZ2
PDB IDs		1JPL 1JUQ 1LF8 1P4U 1WR6 1YD8	2MX7
Enriched GO Terms of Interacting Partners?
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