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ADRA2A and GNAI1
Data Source:
HPRD
(in vitro)
ADRA2A
GNAI1
Description
adrenoceptor alpha 2A
G protein subunit alpha i1
Image
GO Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Basolateral Plasma Membrane
Receptor Complex
Dopaminergic Synapse
Nucleus
Cytoplasm
Lysosomal Membrane
Centrosome
Heterotrimeric G-protein Complex
Plasma Membrane
Midbody
Membrane Raft
Extracellular Exosome
Cell Cortex Region
Molecular Function
G Protein-coupled Receptor Activity
Alpha2-adrenergic Receptor Activity
Protein Binding
Protein Kinase Binding
Alpha-1B Adrenergic Receptor Binding
Alpha-2C Adrenergic Receptor Binding
Thioesterase Binding
Heterotrimeric G-protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Epinephrine Binding
Norepinephrine Binding
Magnesium Ion Binding
G Protein-coupled Receptor Binding
GTPase Activity
Protein Binding
GTP Binding
GDP Binding
G-protein Beta/gamma-subunit Complex Binding
G Protein-coupled Serotonin Receptor Binding
GTPase Activating Protein Binding
Biological Process
Positive Regulation Of Cytokine Production
Regulation Of Smooth Muscle Contraction
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
Ras Protein Signal Transduction
Rho Protein Signal Transduction
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Norepinephrine Secretion
Regulation Of Vasoconstriction
Actin Cytoskeleton Organization
Platelet Activation
Positive Regulation Of Cell Migration
Activation Of Protein Kinase Activity
Activation Of Protein Kinase B Activity
Negative Regulation Of Epinephrine Secretion
Cellular Response To Hormone Stimulus
Receptor Transactivation
Glucose Homeostasis
Fear Response
Positive Regulation Of Potassium Ion Transport
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity
Negative Regulation Of Calcium Ion-dependent Exocytosis
Negative Regulation Of Insulin Secretion
Regulation Of Insulin Secretion
Intestinal Absorption
Negative Regulation Of Lipid Catabolic Process
Positive Regulation Of Membrane Protein Ectodomain Proteolysis
Negative Regulation Of Calcium Ion Transport
Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Adrenergic Receptor Signaling Pathway
Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway
Phospholipase C-activating Adrenergic Receptor Signaling Pathway
Positive Regulation Of Wound Healing
Negative Regulation Of Calcium Ion Transmembrane Transporter Activity
Regulation Of Synaptic Vesicle Exocytosis
Protein Folding
Cell Cycle
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
Response To Peptide Hormone
Regulation Of CAMP-mediated Signaling
Negative Regulation Of Synaptic Transmission
Cell Division
Regulation Of Mitotic Spindle Organization
Cellular Response To Forskolin
Positive Regulation Of Protein Localization To Cell Cortex
Pathways
Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism
PLC beta mediated events
PLC beta mediated events
Adenylate cyclase inhibitory pathway
Adenylate cyclase inhibitory pathway
G-protein activation
ADP signalling through P2Y purinoceptor 12
Adrenaline,noradrenaline inhibits insulin secretion
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (s) signalling events
G alpha (i) signalling events
G alpha (i) signalling events
G alpha (z) signalling events
Regulation of insulin secretion
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Extra-nuclear estrogen signaling
ADORA2B mediated anti-inflammatory cytokines production
Drugs
Amphetamine
Tramadol
Bethanidine
Ziprasidone
Cabergoline
Ropinirole
Dihydroergotamine
Amitriptyline
Clozapine
Norepinephrine
Mirtazapine
Phenylpropanolamine
Loxapine
Pramipexole
Prochlorperazine
Dipivefrin
Prazosin
Chlorpromazine
Brimonidine
Haloperidol
Nortriptyline
Amoxapine
Amoxapine
Lamotrigine
Clonidine
Lisuride
Guanabenz
Dexmedetomidine
Trazodone
Epinephrine
Phentolamine
Ergotamine
Tizanidine
Apomorphine
Paroxetine
Trimipramine
Epinastine
Tolazoline
Fenoldopam
Pseudoephedrine
Benzphetamine
Phenoxybenzamine
Maprotiline
Oxymetazoline
Apraclonidine
Methyldopa
Guanfacine
Ergoloid mesylate
Promethazine
Carvedilol
Nefazodone
Desipramine
Escitalopram
Pergolide
Bromocriptine
Quetiapine
Aripiprazole
Paliperidone
Ephedra sinica root
Mephentermine
Yohimbine
Methotrimeprazine
4-Methoxyamphetamine
Dextroamphetamine
Metamfetamine
Periciazine
Zuclopenthixol
Celiprolol
Dronedarone
Lofexidine
Epicept NP-1
Mianserin
Pizotifen
Asenapine
Ocaperidone
Droxidopa
Flupirtine
Esmirtazapine
Xylometazoline
Levonordefrin
Naphazoline
Lurasidone
Dosulepin
Etoperidone
Lorpiprazole
Cirazoline
Moxisylyte
Aranidipine
Moxonidine
Pirlindole
Pipamperone
Setiptiline
Racepinephrine
Dihydroergocornine
DL-Methylephedrine
DL-Methylephedrine
Xylazine
Indigotindisulfonic acid
Rilmenidine
Tiapride
Dihydroergocristine
Aripiprazole lauroxil
Guanosine-5'-Diphosphate
Tetrafluoroaluminate Ion
Diseases
GWAS
Fasting blood glucose (
20081858
22581228
)
Fasting blood glucose (BMI interaction) (
22581228
)
Fish- and plant-related diet (
32066663
)
Homeostasis model assessment of beta-cell function (
20081858
)
Longitudinal alcohol consumption (
26081443
)
Platelet aggregation (
20526338
29185836
)
Cognitive decline rate in late mild cognitive impairment (
26252872
)
Emphysema annual change measurement in smokers (adjusted lung density) (
31324189
)
Night sleep phenotypes (
27126917
)
Post bronchodilator FEV1 (
26634245
)
Interacting Genes
14 interacting genes:
ADRB1
EIF2B1
GGA3
GNAI1
GNAI2
GNAO1
GNB1
GNG2
GRK2
PPP1R9B
PRKCD
SNTA1
UCHL1
YWHAZ
62 interacting genes:
ADCY5
ADRA2A
ADRB2
CCR5
CD47
CNR1
CRHR1
CXCR4
DRD3
DRD4
EPOR
ESR1
FFAR1
GNAO1
GNB2
GNB4
GNG2
GPR1
GPR143
GPSM1
GPSM2
GPSM3
HRH4
HTR2A
IGF1R
KLHL3
MTNR1A
MTNR1B
NGB
NUCB1
NUMA1
OPRD1
OPRM1
PCP2
PDE6D
PTEN
PTPRU
RANGAP1
RASD1
RGS10
RGS12
RGS14
RGS16
RGS17
RGS18
RGS19
RGS20
RGS4
RGS7
RIC8A
S1PR1
S1PR2
S1PR3
S1PR4
S1PR5
SSTR2
SSTR3
STRN
THAP7
TSHR
VIPR1
WASF1
Entrez ID
150
2770
HPRD ID
00078
00756
Ensembl ID
ENSG00000150594
ENSG00000127955
Uniprot IDs
P08913
P63096
PDB IDs
1HLL
1HO9
1HOD
1HOF
6K42
6KUX
6KUY
1KJY
1Y3A
2G83
2GTP
2IK8
2OM2
2XNS
3ONW
3QE0
3QI2
3UMR
3UMS
4G5Q
5JS7
5JS8
5TDH
6CMO
6CRK
6DDE
6DDF
6KPF
6KPG
6LFM
6LFO
6LML
6N4B
6OMM
6OS9
6OSA
6OT0
6PB0
6PB1
6PT0
6QNO
6VU8
6XBJ
6XBK
6XBL
6XBM
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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