GGA3 and M6PR

Data Source:
HPRD (in vitro, two hybrid)

		GGA3	M6PR
Description		golgi associated, gamma adaptin ear containing, ARF binding protein 3	mannose-6-phosphate receptor, cation dependent
Image
GO Annotations	Cellular Component	Lysosome Golgi Apparatus Trans-Golgi Network Endosome Membrane Early Endosome Membrane Protein-containing Complex Recycling Endosome Membrane	Lysosomal Membrane Endosome Late Endosome Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Membrane Transport Vesicle Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Small GTPase Binding Ubiquitin Binding Protein-containing Complex Binding	Transmembrane Signaling Receptor Activity Protein Binding Protein Domain Specific Binding Retromer Complex Binding
	Biological Process	Protein Targeting To Lysosome Intracellular Protein Transport Regulation Of Protein Stability Protein Destabilization Endocytic Recycling Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Cellular Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Amyloid-beta Formation	Protein Targeting To Lysosome Receptor-mediated Endocytosis Lysosomal Transport Endosome To Lysosome Transport Secretion Of Lysosomal Enzymes Membrane Organization
Pathways		TBC/RABGAPs MET receptor recycling Amyloid fiber formation	Lysosome Vesicle Biogenesis Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Alglucosidase alfa 1-3 Sugar Ring of Pentamannosyl 6-Phosphate alpha-D-mannose 6-phosphate
Diseases
GWAS			SjÃ¶gren's syndrome ( 28076899) Total cholesterol levels ( 30275531)
Interacting Genes		38 interacting genes: ADRA2A ADRA2B AFTPH AP1S2 ARAP3 ARF1 ARF3 CDKN2A CLINT1 CLTC CYTH2 DAZAP2 EGFR GGA1 GGA2 IGF2R LITAF LRP10 M6PR P4HA3 PACS1 PLEKHB2 RABEP1 RNF11 RNF214 RPS27A STAB1 SYNRG TBC1D3 TOLLIP TRAPPC6A TRIM23 TSG101 UBC UPRT VPS11 VPS18 ZNF497	12 interacting genes: DUSP12 GGA1 GGA2 GGA3 GIMAP5 HSPA12A JUN KTN1 NINJ2 PLIN3 REN SMCO4
Entrez ID		23163	4074
HPRD ID		10443	01106
Ensembl ID		ENSG00000125447	ENSG00000003056
Uniprot IDs		A8K6M0 B7Z456 Q9NZ52	F5GX30 P20645
PDB IDs		1JPL 1JUQ 1LF8 1P4U 1WR6 1YD8	1JUQ
Enriched GO Terms of Interacting Partners?
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