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CRYAB and BAG3
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, pull down, pull down)
CRYAB
BAG3
Description
crystallin alpha B
BAG cochaperone 3
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Golgi Apparatus
Cytosol
Cell Surface
Postsynaptic Density
Microtubule Cytoskeleton
Z Disc
Axon
M Band
Actin Filament Bundle
Protein-containing Complex
Dendritic Spine
Perikaryon
Extracellular Exosome
Synaptic Membrane
Cardiac Myofibril
Stress Fiber
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Aggresome
Z Disc
Neuron Projection
Chaperone Complex
Molecular Function
Amyloid-beta Binding
Structural Molecule Activity
Structural Constituent Of Eye Lens
Protein Binding
Microtubule Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
Metal Ion Binding
Unfolded Protein Binding
Adenyl-nucleotide Exchange Factor Activity
Protein Binding
Heat Shock Protein Binding
Protein-containing Complex Binding
Cadherin Binding
Dynein Intermediate Chain Binding
Chaperone Binding
Biological Process
Response To Hypoxia
Lens Development In Camera-type Eye
Protein Folding
Muscle Contraction
Tubulin Complex Assembly
Muscle Organ Development
Multicellular Organism Aging
Regulation Of Cell Death
Negative Regulation Of Cell Growth
Microtubule Polymerization Or Depolymerization
Negative Regulation Of Protein-containing Complex Assembly
Response To Estradiol
Negative Regulation Of Intracellular Transport
Response To Hydrogen Peroxide
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Transcription, DNA-templated
Protein Stabilization
Stress-activated MAPK Cascade
Apoptotic Process Involved In Morphogenesis
Cellular Response To Gamma Radiation
Regulation Of Cellular Response To Heat
Negative Regulation Of Amyloid Fibril Formation
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Autophagosome Assembly
Protein Folding
Brain Development
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Striated Muscle Cell Apoptotic Process
Spinal Cord Development
Cellular Response To Heat
Cellular Response To Unfolded Protein
Positive Regulation Of Protein Import Into Nucleus
Negative Regulation Of Apoptotic Process
Muscle Cell Cellular Homeostasis
Positive Regulation Of Protein Export From Nucleus
Regulation Of Catalytic Activity
Protein Stabilization
Chaperone-mediated Autophagy
Aggresome Assembly
Cellular Response To Mechanical Stimulus
Chaperone-mediated Protein Transport
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Protein Transport Along Microtubule
Regulation Of Cellular Response To Heat
Negative Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Aggrephagy
Pathways
HSF1-dependent transactivation
Regulation of HSF1-mediated heat shock response
Drugs
Diseases
Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy
GWAS
Birth weight (
31043758
)
PR interval (
32439900
)
Diastolic blood pressure (
27841878
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Heart failure (
31919418
)
Idiopathic dilated cardiomyopathy (
21459883
)
Left ventricular ejection fraction (
32382064
32605384
)
Left ventricular end-systolic volume (
32382064
)
Parkinson's disease (
32201043
27182965
28892059
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Interacting Genes
54 interacting genes:
ACOT7
APOC2
APP
AVP
B2M
BAG3
BCL2L1
BMPR2
CAPN3
CASP3
CCL22
CCND1
CRYAA
CRYAA2
CRYBA1
CRYBB2
CRYGC
CRYGD
CRYGS
CS
DDX20
DES
EPB41
FCGR2A
FGF2
GFAP
GORASP2
HBA1
HSPB1
HSPB2
HSPB6
HSPB8
INS
KRTAP19-5
KRTAP6-1
KRTAP8-1
LALBA
MDH2
MIP
MRPL11
NGF
PRKAG3
PRNP
PSMA3
SCN5A
SLC13A1
SNCA
SOD1
SQSTM1
TNPO2
TRAPPC6A
TTN
UBE2D1
VEGFA
75 interacting genes:
ACD
ARRDC3
ATN1
ATXN7L2
BAIAP2L1
BCL2
CRYAB
CTDSP1
CYSRT1
CYSTM1
DAZAP2
DNM2
DTX3
DVL1
DVL2
DYNLT1
EGR4
EYA2
FAM168B
FAM189A2
FBXO7
FOXD4L1
GGN
GLIS3
HELT
HSPA1A
HSPA5
HSPA8
HSPB1
HSPB2
HSPB2-C11orf52
HSPB7
HSPB8
INCA1
LENG8
LITAF
LRRK1
LRRK2
MAGED1
MDFI
MRPL38
NIBAN3
NOTO
NR1H3
PDE9A
PDLIM7
PIH1D2
PLA2G10
PLCG1
PLEKHB1
POT1
PRDM6
PRKAR1B
PRR34
PTPN21
RUNX1
SF3B4
SHISA6
SIAH1
SPRY2
SRPK2
TBC1D3B
TBC1D3G
TINF2
TMEM174
TNK2
TP53BP2
TRIB3
TRIM27
TRIP6
TSC1
UNKL
VPS37B
WBP2
WNK1
Entrez ID
1410
9531
HPRD ID
00428
04860
Ensembl ID
ENSG00000109846
ENSG00000151929
Uniprot IDs
A0A024R3B9
P02511
V9HW27
O95817
PDB IDs
2KLR
2N0K
2WJ7
2Y1Y
2Y1Z
2Y22
2YGD
3J07
3L1G
3SGM
3SGN
3SGO
3SGP
3SGR
3SGS
4M5S
4M5T
5VVV
6BP9
Enriched GO Terms of Interacting Partners
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