CRYAB and CCND1

Data Source:
BioGRID (enzymatic study)

		CRYAB	CCND1
Description		crystallin alpha B	cyclin D1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cell Surface Postsynaptic Density Microtubule Cytoskeleton Z Disc Axon M Band Actin Filament Bundle Protein-containing Complex Dendritic Spine Perikaryon Extracellular Exosome Synaptic Membrane Cardiac Myofibril	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Cytosol Bicellular Tight Junction Transcription Repressor Complex Nuclear Membrane
	Molecular Function	Amyloid-beta Binding Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Microtubule Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding Unfolded Protein Binding	Transcription Corepressor Activity Protein Kinase Activity Protein Binding Transcription Factor Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding Protein-containing Complex Binding Proline-rich Region Binding
	Biological Process	Response To Hypoxia Lens Development In Camera-type Eye Protein Folding Muscle Contraction Tubulin Complex Assembly Muscle Organ Development Multicellular Organism Aging Regulation Of Cell Death Negative Regulation Of Cell Growth Microtubule Polymerization Or Depolymerization Negative Regulation Of Protein-containing Complex Assembly Response To Estradiol Negative Regulation Of Intracellular Transport Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transcription, DNA-templated Protein Stabilization Stress-activated MAPK Cascade Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Regulation Of Cellular Response To Heat Negative Regulation Of Amyloid Fibril Formation Negative Regulation Of Reactive Oxygen Species Metabolic Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Re-entry Into Mitotic Cell Cycle Positive Regulation Of Protein Phosphorylation Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Cellular Response To DNA Damage Stimulus Lactation Response To Iron Ion Response To X-ray Response To Organonitrogen Compound Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Wnt Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Mitotic G1 DNA Damage Checkpoint Response To Magnesium Ion Response To Estradiol Response To Vitamin E Leydig Cell Differentiation Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Response To Drug Response To Estrogen Response To Leptin Mitotic Cell Cycle Phase Transition Fat Cell Differentiation Response To Ethanol Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Cycle Cell Division Response To Corticosterone Response To Calcium Ion Mammary Gland Alveolus Development Response To UV-A Negative Regulation Of Cell Cycle Arrest Liver Regeneration Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		HSF1-dependent transactivation	SCF(Skp2)-mediated degradation of p27/p21 Pre-NOTCH Transcription and Translation RMTs methylate histone arginines Interleukin-4 and Interleukin-13 signaling Cyclin D associated events in G1 Ubiquitin-dependent degradation of Cyclin D Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates Cell Cycle Transcriptional Regulation by VENTX Transcriptional regulation by RUNX2 Regulation of RUNX1 Expression and Activity RUNX3 regulates WNT signaling RUNX3 regulates p14-ARF Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs			Acetylsalicylic acid Arsenic trioxide Encorafenib Bryostatin 1
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy	Hairy-cell leukemia von Hippel-Lindau syndrome Esophageal cancer Oral cancer Multiple myeloma Laryngeal cancer Breast cancer
GWAS		Birth weight ( 31043758) PR interval ( 32439900)	Adult body size ( 32376654) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Body fat distribution (arm fat ratio) ( 30664634) Breast cancer ( 29059683 20453838) Breast cancer (early onset) ( 24493630) Breast size ( 22747683 27182965) Craniofacial microsomia ( 26853712) Cutaneous malignant melanoma ( 32341527 26237428) Diastolic blood pressure ( 27841878) Height ( 25429064) Hip circumference ( 25673412) Idiopathic dilated cardiomyopathy ( 29495422) Immunoglobulin light chain (AL) amyloidosis ( 28025584) Melanoma ( 28212542) Multiple myeloma (IgH translocation) ( 23502783) Nevus count or cutaneous melanoma ( 32341527 30429480) Offspring birth weight ( 31043758) Refractive error ( 32231278) Total body bone mineral density ( 29304378) Type 2 diabetes ( 30297969 32499647 30718926) White blood cell count ( 32888494)
Interacting Genes		54 interacting genes: ACOT7 APOC2 APP AVP B2M BAG3 BCL2L1 BMPR2 CAPN3 CASP3 CCL22 CCND1 CRYAA CRYAA2 CRYBA1 CRYBB2 CRYGC CRYGD CRYGS CS DDX20 DES EPB41 FCGR2A FGF2 GFAP GORASP2 HBA1 HSPB1 HSPB2 HSPB6 HSPB8 INS KRTAP19-5 KRTAP6-1 KRTAP8-1 LALBA MDH2 MIP MRPL11 NGF PRKAG3 PRNP PSMA3 SCN5A SLC13A1 SNCA SOD1 SQSTM1 TNPO2 TRAPPC6A TTN UBE2D1 VEGFA	80 interacting genes: AKAP8 AR ARID4A ATF2 BCAS3 BRCA1 BRCA2 BRINP1 BTRC CALM1 CAMK1 CCNDBP1 CDC14B CDH13 CDK4 CDK6 CDK8 CDKN1A CDKN1B CRYAB CTNNB1 CUL3 DMTF1 EP300 ESR1 FANCC FBXO31 FBXO4 FOS GSK3B HDAC3 HERC5 IFI27 IGFBP3 INSM1 JUN JUND KAT2B KLK7 KLK9 LPL MAPK11 MCM10 MCM7 MYBL2 NCOA1 NCOA3 NPDC1 ORC4 PCNA POLR1B PPP3R2 PRKACA PRKN RABEP1 RAD51 RANBP9 RB1 RBL1 RBL2 RBX1 RFC1 RUNX1 SMAD1 SP1 STAT3 TAF1 TBC1D2 TDRD7 THRA THRB TP73 TRMO TSC2 TSTD2 UBTF UHRF2 USP2 XPO1 ZNF510
Entrez ID		1410	595
HPRD ID		00428	01346
Ensembl ID		ENSG00000109846	ENSG00000110092
Uniprot IDs		A0A024R3B9 P02511 V9HW27	P24385 Q6FI00
PDB IDs		2KLR 2N0K 2WJ7 2Y1Y 2Y1Z 2Y22 2YGD 3J07 3L1G 3SGM 3SGN 3SGO 3SGP 3SGR 3SGS 4M5S 4M5T 5VVV 6BP9	2W96 2W99 2W9F 2W9Z 5VZU 6P8E 6P8F 6P8G 6P8H
Enriched GO Terms of Interacting Partners?
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