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CRYAB and SLC13A1
Data Source:
BioGRID
(protein complementation assay)
CRYAB
SLC13A1
Description
crystallin alpha B
solute carrier family 13 member 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Golgi Apparatus
Cytosol
Cell Surface
Postsynaptic Density
Microtubule Cytoskeleton
Z Disc
Axon
M Band
Actin Filament Bundle
Protein-containing Complex
Dendritic Spine
Perikaryon
Extracellular Exosome
Synaptic Membrane
Cardiac Myofibril
Plasma Membrane
Integral Component Of Membrane
Molecular Function
Amyloid-beta Binding
Structural Molecule Activity
Structural Constituent Of Eye Lens
Protein Binding
Microtubule Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
Metal Ion Binding
Unfolded Protein Binding
Sodium:sulfate Symporter Activity
Biological Process
Response To Hypoxia
Lens Development In Camera-type Eye
Protein Folding
Muscle Contraction
Tubulin Complex Assembly
Muscle Organ Development
Multicellular Organism Aging
Regulation Of Cell Death
Negative Regulation Of Cell Growth
Microtubule Polymerization Or Depolymerization
Negative Regulation Of Protein-containing Complex Assembly
Response To Estradiol
Negative Regulation Of Intracellular Transport
Response To Hydrogen Peroxide
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Transcription, DNA-templated
Protein Stabilization
Stress-activated MAPK Cascade
Apoptotic Process Involved In Morphogenesis
Cellular Response To Gamma Radiation
Regulation Of Cellular Response To Heat
Negative Regulation Of Amyloid Fibril Formation
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Sodium Ion Transport
Sulfate Transport
Anion Transmembrane Transport
Sulfate Transmembrane Transport
Pathways
HSF1-dependent transactivation
Sodium-coupled sulphate, di- and tri-carboxylate transporters
Drugs
Diseases
Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy
GWAS
Birth weight (
31043758
)
PR interval (
32439900
)
Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) (
23648065
)
High density lipoprotein cholesterol levels (
30498476
)
Systolic blood pressure (
30578418
)
Interacting Genes
54 interacting genes:
ACOT7
APOC2
APP
AVP
B2M
BAG3
BCL2L1
BMPR2
CAPN3
CASP3
CCL22
CCND1
CRYAA
CRYAA2
CRYBA1
CRYBB2
CRYGC
CRYGD
CRYGS
CS
DDX20
DES
EPB41
FCGR2A
FGF2
GFAP
GORASP2
HBA1
HSPB1
HSPB2
HSPB6
HSPB8
INS
KRTAP19-5
KRTAP6-1
KRTAP8-1
LALBA
MDH2
MIP
MRPL11
NGF
PRKAG3
PRNP
PSMA3
SCN5A
SLC13A1
SNCA
SOD1
SQSTM1
TNPO2
TRAPPC6A
TTN
UBE2D1
VEGFA
31 interacting genes:
ACOT2
ACTR10
APLP2
ARL6IP1
ASS1
CD59
COQ5
COQ9
CRYAB
DYNLL1
FTL
GRN
HSPA1A
MKRN1
NDUFS5
OGDHL
PDZK1
PNPLA6
PRSS8
RHOA
SDHD
SEC61A1
SELPLG
SERPINA1
SLC9A3R1
SLC9A3R2
TBRG1
TM4SF1
TMED10
TP53I11
TSPAN3
Entrez ID
1410
6561
HPRD ID
00428
08394
Ensembl ID
ENSG00000109846
ENSG00000081800
Uniprot IDs
A0A024R3B9
P02511
V9HW27
A4D0X1
Q2NKK0
Q9BZW2
PDB IDs
2KLR
2N0K
2WJ7
2Y1Y
2Y1Z
2Y22
2YGD
3J07
3L1G
3SGM
3SGN
3SGO
3SGP
3SGR
3SGS
4M5S
4M5T
5VVV
6BP9
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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