CRYAB and CAPN3

Data Source:
BioGRID (two hybrid)

		CRYAB	CAPN3
Description		crystallin alpha B	calpain 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cell Surface Postsynaptic Density Microtubule Cytoskeleton Z Disc Axon M Band Actin Filament Bundle Protein-containing Complex Dendritic Spine Perikaryon Extracellular Exosome Synaptic Membrane Cardiac Myofibril	Intracellular Anatomical Structure Nucleus Cytoplasm Cytosol Plasma Membrane Myofibril Z Disc T-tubule Protein-containing Complex
	Molecular Function	Amyloid-beta Binding Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Microtubule Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding Unfolded Protein Binding	Catalytic Activity Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Structural Constituent Of Muscle Sodium Ion Binding Titin Binding Ligase Regulator Activity Molecular Adaptor Activity
	Biological Process	Response To Hypoxia Lens Development In Camera-type Eye Protein Folding Muscle Contraction Tubulin Complex Assembly Muscle Organ Development Multicellular Organism Aging Regulation Of Cell Death Negative Regulation Of Cell Growth Microtubule Polymerization Or Depolymerization Negative Regulation Of Protein-containing Complex Assembly Response To Estradiol Negative Regulation Of Intracellular Transport Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transcription, DNA-templated Protein Stabilization Stress-activated MAPK Cascade Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Regulation Of Cellular Response To Heat Negative Regulation Of Amyloid Fibril Formation Negative Regulation Of Reactive Oxygen Species Metabolic Process	Proteolysis Apoptotic Process Muscle Organ Development Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Response To Muscle Activity Protein Catabolic Process Myofibril Assembly Protein Destabilization Negative Regulation Of Protein Sumoylation Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Sarcomere Organization Regulation Of Myoblast Differentiation Positive Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Muscle Cell Cellular Homeostasis Regulation Of Catalytic Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Calcium Ion Muscle Structure Development Protein-containing Complex Assembly G1 To G0 Transition Involved In Cell Differentiation Cellular Response To Calcium Ion Cellular Response To Salt Stress Protein Localization To Membrane Self Proteolysis Calcium-dependent Self Proteolysis
Pathways		HSF1-dependent transactivation	Degradation of the extracellular matrix
Drugs			L-aminocarnityl-succinyl-leucyl-argininal-diethylacetal
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy	Calpainopathy; Limb-girdle muscular dystrophy 2A (LGMD2A) Limb-girdle muscular dystrophy (LGMD)
GWAS		Birth weight ( 31043758) PR interval ( 32439900)	Fibrinogen levels ( 28107422 26561523) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Metabolite levels ( 23823483) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Triglyceride levels ( 32203549 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068 25961943 20686565)
Interacting Genes		54 interacting genes: ACOT7 APOC2 APP AVP B2M BAG3 BCL2L1 BMPR2 CAPN3 CASP3 CCL22 CCND1 CRYAA CRYAA2 CRYBA1 CRYBB2 CRYGC CRYGD CRYGS CS DDX20 DES EPB41 FCGR2A FGF2 GFAP GORASP2 HBA1 HSPB1 HSPB2 HSPB6 HSPB8 INS KRTAP19-5 KRTAP6-1 KRTAP8-1 LALBA MDH2 MIP MRPL11 NGF PRKAG3 PRNP PSMA3 SCN5A SLC13A1 SNCA SOD1 SQSTM1 TNPO2 TRAPPC6A TTN UBE2D1 VEGFA	30 interacting genes: AMOT C1QTNF9 CCDC102B CEP76 CMYA5 CRYAB DYSF EXOC8 FLNC FNDC3B GTPBP3 KANK2 MAP1LC3C MMP2 MYBPC1 MYBPH NECAB2 NTAQ1 OSGIN1 POMP PREPL PSMC3 PSMD1 RNF167 RUFY3 TFCP2 TRIM55 TRIM63 TTN YWHAQ
Entrez ID		1410	825
HPRD ID		00428	00255
Ensembl ID		ENSG00000109846	ENSG00000092529
Uniprot IDs		A0A024R3B9 P02511 V9HW27	A0A0S2Z3E1 P20807
PDB IDs		2KLR 2N0K 2WJ7 2Y1Y 2Y1Z 2Y22 2YGD 3J07 3L1G 3SGM 3SGN 3SGO 3SGP 3SGR 3SGS 4M5S 4M5T 5VVV 6BP9	1Y9V 4OKH 6BDT 6BGP 6BJD 6BKJ
Enriched GO Terms of Interacting Partners?
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