UBE2F and NAE1

Data Source:
BioGRID (enzymatic study)

		UBE2F	NAE1
Description		ubiquitin conjugating enzyme E2 F (putative)	NEDD8 activating enzyme E1 subunit 1
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GO Annotations	Cellular Component	Nucleus Cytosol	Cytoplasm Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Protein Binding ATP Binding NEDD8 Transferase Activity NEDD8 Conjugating Enzyme Activity	Protein Binding NEDD8 Activating Enzyme Activity Ubiquitin Protein Ligase Binding Protein Heterodimerization Activity
	Biological Process	Protein Phosphopantetheinylation Post-translational Protein Modification Protein Neddylation	Signal Transduction Protein Phosphopantetheinylation Protein Modification By Small Protein Conjugation Mitotic DNA Replication Checkpoint Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Protein Neddylation Neuron Apoptotic Process
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Neddylation
Drugs			ATP
Diseases
GWAS		Lean body mass ( 28552196)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		12 interacting genes: CUL1 CUL5 DCUN1D1 DCUN1D2 DCUN1D5 LCN2 NAE1 PAX6 RC3H1 RNF34 RNF7 UBA3	10 interacting genes: ALG8 APP GARS1 NEDD8 SREBF2 TP53BP2 TRIP12 UBA3 UBE2F UBQLN4
Entrez ID		140739	8883
HPRD ID		14812	04545
Ensembl ID		ENSG00000184182	ENSG00000159593
Uniprot IDs		Q969M7	Q13564
PDB IDs		2EDI 3FN1 4GBA	1R4M 1R4N 1TT5 1YOV 2NVU 3DBH 3DBL 3DBR 3GZN
Enriched GO Terms of Interacting Partners?
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