NAE1 and GARS1

Data Source:
BioGRID (pull down, affinity chromatography technology)

		NAE1	GARS1
Description		NEDD8 activating enzyme E1 subunit 1	glycyl-tRNA synthetase 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Protein-containing Complex	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Axon Extracellular Exosome
	Molecular Function	Protein Binding NEDD8 Activating Enzyme Activity Ubiquitin Protein Ligase Binding Protein Heterodimerization Activity	Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) Activity Glycine-tRNA Ligase Activity Protein Binding ATP Binding Transferase Activity Identical Protein Binding Protein Dimerization Activity
	Biological Process	Signal Transduction Protein Phosphopantetheinylation Protein Modification By Small Protein Conjugation Mitotic DNA Replication Checkpoint Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Protein Neddylation Neuron Apoptotic Process	TRNA Aminoacylation For Protein Translation Glycyl-tRNA Aminoacylation Diadenosine Tetraphosphate Biosynthetic Process Mitochondrial Glycyl-tRNA Aminoacylation
Pathways		Neddylation	Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation
Drugs		ATP	Glycine
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Distal hereditary motor neuropathies (dHMN)
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		10 interacting genes: ALG8 APP GARS1 NEDD8 SREBF2 TP53BP2 TRIP12 UBA3 UBE2F UBQLN4	11 interacting genes: CD44 CELSR2 DUX4 EEF1D HSPB2 IARS1 LINC01554 MAP3K10 MAPK8 NAE1 NEDD8
Entrez ID		8883	2617
HPRD ID		04545	02617
Ensembl ID		ENSG00000159593	ENSG00000106105
Uniprot IDs		Q13564	A0A090N8G0 A0A6Q8PGW4 P41250
PDB IDs		1R4M 1R4N 1TT5 1YOV 2NVU 3DBH 3DBL 3DBR 3GZN	2PME 2PMF 2Q5H 2Q5I 2ZT5 2ZT6 2ZT7 2ZT8 2ZXF 4KQE 4KR2 4KR3 4QEI 5E6M
Enriched GO Terms of Interacting Partners?
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