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NAE1 and SREBF2
Data Source:
BioGRID
(two hybrid)
NAE1
SREBF2
Description
NEDD8 activating enzyme E1 subunit 1
sterol regulatory element binding transcription factor 2
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Protein-containing Complex
Golgi Membrane
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
ER To Golgi Transport Vesicle Membrane
SREBP-SCAP-Insig Complex
Intracellular Membrane-bounded Organelle
Molecular Function
Protein Binding
NEDD8 Activating Enzyme Activity
Ubiquitin Protein Ligase Binding
Protein Heterodimerization Activity
C-8 Sterol Isomerase Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Protein Binding
Protein C-terminus Binding
Protein Dimerization Activity
E-box Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Signal Transduction
Protein Phosphopantetheinylation
Protein Modification By Small Protein Conjugation
Mitotic DNA Replication Checkpoint
Regulation Of Apoptotic Process
Regulation Of Neuron Apoptotic Process
Post-translational Protein Modification
Protein Neddylation
Neuron Apoptotic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Lipid Metabolic Process
Cholesterol Metabolic Process
Regulation Of Notch Signaling Pathway
Cellular Response To Starvation
Positive Regulation Of Cholesterol Storage
SREBP Signaling Pathway
Cholesterol Homeostasis
Regulation Of Cholesterol Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Low-density Lipoprotein Particle Stimulus
Cellular Response To Laminar Fluid Shear Stress
Negative Regulation Of Cholesterol Efflux
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Pathways
Neddylation
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Regulation of cholesterol biosynthesis by SREBP (SREBF)
PPARA activates gene expression
Activation of gene expression by SREBF (SREBP)
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
ATP
Diseases
GWAS
Apolipoprotein A1 levels (
32203549
)
HDL cholesterol levels (
32203549
)
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Birth weight (
31043758
27680694
)
General cognitive ability (
29844566
)
Processed meat consumption (
32066663
)
Refractive error (
32231278
)
Schizophrenia (
25056061
29483656
)
Interacting Genes
10 interacting genes:
ALG8
APP
GARS1
NEDD8
SREBF2
TP53BP2
TRIP12
UBA3
UBE2F
UBQLN4
50 interacting genes:
ABLIM1
ABLIM2
ARHGEF1
ARRB1
ATF7IP
ATXN1
AURKA
CASP3
CASP8AP2
COPS5
CREB1
CREBBP
EGR1
EP300
FHL2
FHL3
GOLGB1
HNF4A
HSPA5
INSIG1
INSIG2
ITGB4
KLF13
KPNB1
LINC00839
LZTR1
MAPK1
MAPK3
MRPS6
MTNR1B
NAE1
NFYA
NFYC
OS9
PIAS1
PIAS2
PIAS3
PSMD4
RAB11B
SCAP
SLC4A4
SMAD3
SP1
SPTBN1
SUMO1
TTC1
UBE2I
ZDHHC17
ZMYM2
ZYX
Entrez ID
8883
6721
HPRD ID
04545
02726
Ensembl ID
ENSG00000159593
ENSG00000198911
Uniprot IDs
Q13564
A0A024R1Q0
Q12772
PDB IDs
1R4M
1R4N
1TT5
1YOV
2NVU
3DBH
3DBL
3DBR
3GZN
1UKL
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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