UBE2F and RNF7

Data Source:
BioGRID (pull down, pull down, pull down, pull down, x-ray crystallography)

		UBE2F	RNF7
Description		ubiquitin conjugating enzyme E2 F (putative)	ring finger protein 7
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GO Annotations	Cellular Component	Nucleus Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding ATP Binding NEDD8 Transferase Activity NEDD8 Conjugating Enzyme Activity	Copper Ion Binding Protein Binding Zinc Ion Binding NEDD8 Transferase Activity Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Cullin Family Protein Binding
	Biological Process	Protein Phosphopantetheinylation Post-translational Protein Modification Protein Neddylation	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Phosphopantetheinylation Post-translational Protein Modification Protein Neddylation Response To Redox State
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Lean body mass ( 28552196)	Hepatitis C induced liver fibrosis ( 22841784) Pelvic organ prolapse (moderate/severe) ( 26545240)
Interacting Genes		12 interacting genes: CUL1 CUL5 DCUN1D1 DCUN1D2 DCUN1D5 LCN2 NAE1 PAX6 RC3H1 RNF34 RNF7 UBA3	43 interacting genes: APOBEC3F APOBEC3G ASB11 BTRC CASP7 CBFB CDC34 CHFR CSNK2A1 CSNK2B CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CYCS ELOB ELOC ERBIN GEM GHR GLMN IKBKG ITM2C MKRN3 MNAT1 NEDD4 NEDD4L PLA2G15 PMAIP1 SOCS3 TRIM46 TRIM8 UBE2C UBE2D1 UBE2D2 UBE2D4 UBE2F UBE2L3 UBE2M UBE2Q1 UBE2S
Entrez ID		140739	9616
HPRD ID		14812	04840
Ensembl ID		ENSG00000184182	ENSG00000114125
Uniprot IDs		Q969M7	Q9UBF6
PDB IDs		2EDI 3FN1 4GBA	2ECL
Enriched GO Terms of Interacting Partners?
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