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CRX and CCNC
Data Source:
BioGRID
(two hybrid)
CRX
CCNC
Description
cone-rod homeobox
cyclin C
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
RNA Polymerase II Transcription Regulator Complex
Nucleus
Nucleoplasm
Mediator Complex
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Transcription Factor Binding
DNA-binding Transcription Activator Activity
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Nuclear Hormone Receptor Binding
Leucine Zipper Domain Binding
Sequence-specific Double-stranded DNA Binding
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Identical Protein Binding
Biological Process
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Nervous System Development
Visual Perception
Animal Organ Morphogenesis
Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Response To Stimulus
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Transcription By RNA Polymerase II
Pathways
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Generic Transcription Pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
Leber congenital amaurosis (LCR)
Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS
Erectile dysfunction (
30297428
)
Refractive error (
32231278
)
Interacting Genes
112 interacting genes:
AASDHPPT
ABI2
ACBD4
ARIH2
ATG12
ATM
ATP6V0D2
ATXN1
ATXN7
BANF1
BANF2
BANP
BOD1L2
C19orf25
C1orf109
C1orf50
C1orf56
C9orf72
CA8
CCNC
CDKN2C
CFAP206
CREBBP
CSNK1G2-AS1
CTNNA3
DELE1
EIF5A
EP300
FAAP20
FOXH1
GCM2
GLIS2
GUCD1
GYS1
HGS
HNF1B
IGFN1
IPO13
IRX6
KANK2
KAT2A
KLHL32
LARP4
LGALS3
LIMS3
LIMS4
LNX1
LONRF1
M1AP
MDFI
MLLT6
MYO15B
MYOZ1
NEIL2
NFYC
NIP7
NPAS2
NR2E3
NRL
NTF4
OR6B1
OSGIN1
OSTF1
PDC
PICALM
PID1
PNMA6A
POGZ
PPP1R16B
PRKAB2
PRKN
PRR35
PSMA1
PSMB10
PSMF1
QRICH1
RAX2
RBFOX1
RBPMS
RHOXF2
ROR2
SAE1
SDCBP
SEC14L4
SFI1
SMAD3
SMAP1
SMAP2
SMUG1
SOX10
SOX14
SOX3
SOX5
SPG21
STK16
SUFU
SUOX
SZT2
TBX6
TCF7L2
TEX33
TFG
TLE5
TLX3
TNS2
UBXN2B
UBXN7
VPS37C
ZC3H10
ZIC1
ZNF483
ZNF688
80 interacting genes:
ASH2L
BLOC1S2
BTBD2
CCHCR1
CCNH
CDK3
CDK8
CDKN2B
CFAP53
CKS1B
CRX
DYDC1
ERCC3
ESR2
FAM161A
FAM50B
FAM90A1
FOXP2
FOXR2
GADD45GIP1
GLYR1
GOLGA2
GPC4
HSPB1
ISY1
KRT13
KRT15
KRT16
KRT27
KRT31
KRT34
LCN2
LZTS2
MBD3
MBIP
MCM2
MED8
MEOX2
MGST3
MYO15B
NDUFB7
NDUFV2
NEFL
NMNAT1
NRBF2
PAX5
PBXIP1
PLEKHO2
PLIN3
PNMA5
POU6F2
PRPF18
PUF60
RB1
RBM41
REL
RFC5
RIBC1
RPA2
RUSC1
SERTAD3
SHC3
SPAG8
TADA3
TCEANC
TEPSIN
TEX12
TP63
TRAF3IP3
TRIM39
TRIM54
UBE2K
VHL
VTA1
ZFP90
ZNF18
ZNF426
ZNF620
ZNF688
ZNF792
Entrez ID
1406
892
HPRD ID
03748
00456
Ensembl ID
ENSG00000105392
ENSG00000112237
Uniprot IDs
O43186
P24863
Q7Z4L3
PDB IDs
3RGF
4CRL
4F6S
4F6U
4F6W
4F70
4F7J
4F7L
4F7N
4F7S
4G6L
5BNJ
5CEI
5FGK
5HBE
5HBH
5HBJ
5HNB
5HVY
5I5Z
5ICP
5IDN
5IDP
5XQX
5XS2
6QTG
6QTJ
6R3S
6T41
Enriched GO Terms of Interacting Partners
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