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CCNC and RB1
Data Source:
BioGRID
(affinity chromatography technology, enzymatic study)
CCNC
RB1
Description
cyclin C
RB transcriptional corepressor 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Mediator Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Spindle
Cyclin/CDK Positive Transcription Elongation Factor Complex
SWI/SNF Complex
PML Body
Rb-E2F Complex
Molecular Function
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Identical Protein Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Activating Transcription Factor Binding
Transcription Corepressor Activity
Protein Binding
Transcription Factor Binding
Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Phosphoprotein Binding
Importin-alpha Family Protein Binding
Disordered Domain Specific Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Transcription By RNA Polymerase II
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Tissue Homeostasis
Aortic Valve Morphogenesis
Chromatin Remodeling
Regulation Of Transcription, DNA-templated
Negative Regulation Of Protein Kinase Activity
Cell Cycle Arrest
Ras Protein Signal Transduction
Regulation Of Mitotic Cell Cycle
Negative Regulation Of Gene Expression
Viral Process
Cell Differentiation
Negative Regulation Of Cell Growth
Sister Chromatid Biorientation
Neuron Projection Development
Maintenance Of Mitotic Sister Chromatid Cohesion
Glial Cell Apoptotic Process
Skeletal Muscle Cell Differentiation
Neuron Maturation
Enucleate Erythrocyte Differentiation
Negative Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Lipid Kinase Activity
Myoblast Differentiation
Positive Regulation Of Macrophage Differentiation
Negative Regulation Of Cell Cycle
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Negative Regulation Of Smoothened Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Digestive Tract Development
Cell Morphogenesis Involved In Neuron Differentiation
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Inflammatory Response
Striated Muscle Cell Differentiation
Cell Division
Neuron Apoptotic Process
Protein Localization To Chromosome, Centromeric Region
Cellular Response To Xenobiotic Stimulus
Negative Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Cohesin Loading
Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Regulation Of Centromere Complex Assembly
Hepatocyte Apoptotic Process
Negative Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Tau-protein Kinase Activity
Positive Regulation Of Extracellular Matrix Organization
Positive Regulation Of Collagen Fibril Organization
Negative Regulation Of Myofibroblast Differentiation
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Apoptotic Signaling Pathway
Pathways
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Generic Transcription Pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Inhibition of replication initiation of damaged DNA by RB1/E2F1
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Condensation of Prophase Chromosomes
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Oncogene Induced Senescence
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
RUNX2 regulates osteoblast differentiation
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Defective translocation of RB1 mutants to the nucleus
Replication of the SARS-CoV-1 genome
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Replication of the SARS-CoV-2 genome
Drugs
Insulin human
Insulin pork
Diseases
Bladder cancer
Small cell lung cancer
Glioma
Osteosarcoma
Breast cancer
Esophageal cancer
Hepatocellular carcinoma
Chronic myeloid leukemia (CML)
GWAS
Erectile dysfunction (
30297428
)
Refractive error (
32231278
)
Birth weight (
31043758
27680694
)
Chronic kidney disease (
26420894
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Offspring birth weight (
31043758
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Interacting Genes
80 interacting genes:
ASH2L
BLOC1S2
BTBD2
CCHCR1
CCNH
CDK3
CDK8
CDKN2B
CFAP53
CKS1B
CRX
DYDC1
ERCC3
ESR2
FAM161A
FAM50B
FAM90A1
FOXP2
FOXR2
GADD45GIP1
GLYR1
GOLGA2
GPC4
HSPB1
ISY1
KRT13
KRT15
KRT16
KRT27
KRT31
KRT34
LCN2
LZTS2
MBD3
MBIP
MCM2
MED8
MEOX2
MGST3
MYO15B
NDUFB7
NDUFV2
NEFL
NMNAT1
NRBF2
PAX5
PBXIP1
PLEKHO2
PLIN3
PNMA5
POU6F2
PRPF18
PUF60
RB1
RBM41
REL
RFC5
RIBC1
RPA2
RUSC1
SERTAD3
SHC3
SPAG8
TADA3
TCEANC
TEPSIN
TEX12
TP63
TRAF3IP3
TRIM39
TRIM54
UBE2K
VHL
VTA1
ZFP90
ZNF18
ZNF426
ZNF620
ZNF688
ZNF792
190 interacting genes:
AATF
ABL1
AHR
ANKS1A
AR
ARID3B
ATF2
BAAT
BAG1
BDP1
BNC2
BRCA1
BRF1
CASP10
CASP2
CASP3
CASP6
CASP7
CASP8
CASP9
CBX1
CBX4
CCDC180
CCNA1
CCNA2
CCNB1
CCNC
CCND1
CCND2
CCND3
CCNE1
CCNT2
CDC27
CDK1
CDK14
CDK2
CDK3
CDK4
CDK5
CDK6
CDK9
CDKN1A
CDKN1C
CEBPA
CEBPB
CEBPD
CEBPE
CHEK1
CHN2
CLNK
CORO2A
CREG1
CTBP1
CTSV
CUX1
DGKZ
DNMT1
DVL1
DYRK1A
E2F1
E2F2
E2F3
E2F4
E4F1
EID1
ELF1
ENC1
EP300
FANCC
FBP1
FBP2
FOS
FRK
GALNT12
GTF3C2
HBP1
HDAC1
HDAC3
HIF1A
HMGA2
HMGB1
HSPA8
ID2
INS
IRF3
JUN
KAT2B
KAT5
KDM4A
KDM5A
KDM5B
KMT5C
L3MBTL1
LEF1
LIN54
LIN9
LMNA
MAPK1
MAPK14
MAPK3
MAPK9
MCM7
MDM2
MDM4
MNAT1
MNDA
MORF4L1
MORF4L2
MRPS18B
MYC
MYOD1
NCOA6
NDC80
NEFM
ORC1
PA2G4
PAX2
PAX5
PAX6
PELP1
PHB
PIK3R1
PIK3R3
PLA2G12A
PML
POLA1
PPARG
PPIA
PPP1CA
PPP1CB
PPP1CC
PPP1R26
PRDM2
PRKCB
PRKRA
PRMT2
PSMD10
PURA
RABGAP1L
RACK1
RAF1
RASA1
RBAK
RBBP4
RBBP5
RBBP6
RBBP7
RBBP8
RBBP9
RING1
RINT1
RNF123
RNF40
RUNX2
SERPINB2
SHC1
SKP2
SMARCA4
SMARCB1
SMYD2
SNAPC1
SNAPC3
SNW1
SP1
SP3
SPI1
SPIB
STAT3
STX17
SUV39H1
TAF1
TASOR
TBP
TFAP2A
TGM2
THOC1
TMPO
TOP2A
TP53
TRAP1
TRIM27
TRIP11
TRMO
UBE2I
UBTF
USP4
USP7
VDR
XPA
ZBTB16
Entrez ID
892
5925
HPRD ID
00456
01574
Ensembl ID
ENSG00000112237
ENSG00000139687
Uniprot IDs
P24863
Q7Z4L3
A0A024RDV3
P06400
PDB IDs
3RGF
4CRL
4F6S
4F6U
4F6W
4F70
4F7J
4F7L
4F7N
4F7S
4G6L
5BNJ
5CEI
5FGK
5HBE
5HBH
5HBJ
5HNB
5HVY
5I5Z
5ICP
5IDN
5IDP
5XQX
5XS2
6QTG
6QTJ
6R3S
6T41
1AD6
1GH6
1GUX
1H25
1N4M
1O9K
1PJM
2AZE
2QDJ
2R7G
3N5U
3POM
4CRI
4ELJ
4ELL
Enriched GO Terms of Interacting Partners
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