CRX and SMUG1

Data Source:
BioGRID (two hybrid)

		CRX	SMUG1
Description		cone-rod homeobox	single-strand-selective monofunctional uracil-DNA glycosylase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus RNA Polymerase II Transcription Regulator Complex	Fibrillar Center Nucleoplasm Nucleolus Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Nuclear Hormone Receptor Binding Leucine Zipper Domain Binding Sequence-specific Double-stranded DNA Binding	Oxidized Pyrimidine Nucleobase Lesion DNA N-glycosylase Activity DNA Binding Uracil DNA N-glycosylase Activity Protein Binding Single-strand Selective Uracil DNA N-glycosylase Activity DNA N-glycosylase Activity
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Nervous System Development Visual Perception Animal Organ Morphogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Response To Stimulus	Base-excision Repair Depyrimidination
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1
Drugs
Diseases		Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS			Coronary artery disease ( 32469254) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		112 interacting genes: AASDHPPT ABI2 ACBD4 ARIH2 ATG12 ATM ATP6V0D2 ATXN1 ATXN7 BANF1 BANF2 BANP BOD1L2 C19orf25 C1orf109 C1orf50 C1orf56 C9orf72 CA8 CCNC CDKN2C CFAP206 CREBBP CSNK1G2-AS1 CTNNA3 DELE1 EIF5A EP300 FAAP20 FOXH1 GCM2 GLIS2 GUCD1 GYS1 HGS HNF1B IGFN1 IPO13 IRX6 KANK2 KAT2A KLHL32 LARP4 LGALS3 LIMS3 LIMS4 LNX1 LONRF1 M1AP MDFI MLLT6 MYO15B MYOZ1 NEIL2 NFYC NIP7 NPAS2 NR2E3 NRL NTF4 OR6B1 OSGIN1 OSTF1 PDC PICALM PID1 PNMA6A POGZ PPP1R16B PRKAB2 PRKN PRR35 PSMA1 PSMB10 PSMF1 QRICH1 RAX2 RBFOX1 RBPMS RHOXF2 ROR2 SAE1 SDCBP SEC14L4 SFI1 SMAD3 SMAP1 SMAP2 SMUG1 SOX10 SOX14 SOX3 SOX5 SPG21 STK16 SUFU SUOX SZT2 TBX6 TCF7L2 TEX33 TFG TLE5 TLX3 TNS2 UBXN2B UBXN7 VPS37C ZC3H10 ZIC1 ZNF483 ZNF688	37 interacting genes: C10orf55 CDC23 CRX CYSRT1 GLYCTK GPS2 HNRNPF INCA1 KCTD9 KLHDC7B KRTAP13-2 KRTAP15-1 KRTAP26-1 KRTAP6-2 KRTAP8-1 LMO2 MGAT5B NEK6 NOXA1 PEF1 PRKAB2 PROP1 PRR13 PRR35 RBPMS SKIL SMARCD1 SPAG8 TCF7L2 TEKT5 TFG TRAPPC6A TRIP13 VAC14 VENTX YPEL3 ZIC1
Entrez ID		1406	23583
HPRD ID		03748	06376
Ensembl ID		ENSG00000105392	ENSG00000123415
Uniprot IDs		O43186	A0A024RAZ8 A0A0S2Z526 Q53HV7
PDB IDs
Enriched GO Terms of Interacting Partners?
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