C22orf39 and PCSK5

Data Source:
BioGRID (two hybrid)

		C22orf39	PCSK5
Description		chromosome 22 open reading frame 39	proprotein convertase subtilisin/kexin type 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Extracellular Region Extracellular Space Golgi Apparatus Golgi Lumen Trans-Golgi Network Membrane Secretory Granule Integral Component Of Golgi Membrane
	Molecular Function	Protein Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Peptide Binding
	Biological Process		Kidney Development Renin Secretion Into Blood Stream Signal Peptide Processing Cell-cell Signaling Heart Development Embryo Implantation Anterior/posterior Pattern Specification Protein Processing Peptide Hormone Processing Viral Life Cycle Respiratory Tube Development Nerve Growth Factor Processing Limb Morphogenesis Peptide Biosynthetic Process Embryonic Digestive Tract Development Embryonic Skeletal System Development Regulation Of Lipoprotein Lipase Activity Cytokine Precursor Processing
Pathways			NGF processing Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases
GWAS			Alzheimer's disease progression score ( 29860282) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Ankylosing spondylitis ( 30946743) Apolipoprotein B levels ( 32203549) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Diverticular disease ( 30177863) Glucocorticoid-induced osteonecrosis ( 26265699) Glucose homeostasis traits ( 25524916) Height ( 28552196 20881960 25282103 23563607 31562340) Hypotension and cognitive impairment ( 31362389) Inflammatory bowel disease ( 27569725) Intraocular pressure ( 29785010 31959993 30054594) LDL cholesterol levels ( 32203549) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lead levels ( 26025379) Low density lipoprotein cholesterol levels ( 32154731) Male fertility ( 22633400) Metabolite levels (5-HIAA) ( 23319000) Pursuit maintenance gain ( 29064472) Response to fenofibrate (adiponectin levels) ( 23149075) Systemic sclerosis ( 30247649) Takayasu arteritis ( 25604533) Total ventricular volume (Alzheimer's disease interaction) ( 21116278) Vascular brain injury ( 25188341) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412)
Interacting Genes		42 interacting genes: ANKS1A BANP CABP2 CEP76 COL8A1 CRYBA2 CYSRT1 DTX2 EXOSC8 FRS3 GNE GRN HSD3B7 ID2 ID3 INCA1 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP13-2 KRTAP9-2 MAGEA11 MAPK8IP2 MDFI MGAT5B NFATC2IP PCSK5 PFDN5 PLSCR3 PPP2CB PSMA1 RBPMS RECK RIMBP3C SNX32 SYCE1L TRIB3 VWC2L ZNF620	69 interacting genes: ADAMTSL4 AMH APPBP2 ATN1 C17orf50 C22orf39 CACNA1A CCDC33 CREB5 CYSRT1 DBF4B DOCK2 FAM86C1P FARS2 FRS3 GLRX3 GUCD1 HOXA1 HOXB9 INCA1 ITGA6 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-2 KRTAP13-3 KRTAP19-2 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP5-9 LCE1D LCE1F LCE2C LCE3C LCE3D MDFI MEOX2 NBPF19 NOTCH2NLA NR1D2 NR4A3 NUFIP2 OTX1 PCSK6 PLSCR4 PMCH POU4F2 PTPRM REN SHFL SMCP SPRY1 SSC4D STK16 TEKT4 TLE5 TRAF4 TRIB3 TRIM42 TRIP13 USP54 VGLL3 ZNF547 ZNF655 ZNF837
Entrez ID		128977	5125
HPRD ID		14041	08985
Ensembl ID		ENSG00000242259	ENSG00000099139
Uniprot IDs		Q6P5X5	Q92824
PDB IDs
Enriched GO Terms of Interacting Partners?
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